Unsuspected Role for the T-cell Leukemia Protein SCL/tal-1 in Vascular Development

Overview

Journal Genes Dev

Specialty Molecular Biology

Date 1998 Mar 21

PMID 9472016

Citations 79

Authors

J E Visvader

Y Fujiwara

S H Orkin

Affiliations

Soon will be listed here.

Abstract

The transcription factor SCL/tal-1 is essential for blood cell development. Though it is also expressed in vascular endothelium, SCL has been considered dispensable for vessel formation. Through transgenic rescue of hematopoietic defects of SCL-/- embryos and analysis of chimeras generated with SCL-/- ES cells tagged with a transgene expressed in vascular endothelial cells, we show that SCL is essential for angiogenic remodeling of the yolk sac capillary network into complex vitelline vessels. These findings establish a role for SCL in embryonic angiogenesis and argue for critical functions in both embryonic blood and vascular cells, the descendents of the presumptive hemangioblast.

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