Chasing Mavericks: The Quest for Defining Developmental Waves of Hematopoiesis

Overview

Journal Curr Top Dev Biol

Publisher Elsevier

Specialties Biology
Reproductive Medicine

Date 2019 Feb 25

PMID 30797507

Citations 11

Authors

Taylor Cool

E Camilla Forsberg

Affiliations

Soon will be listed here.

Abstract

Hematopoiesis is the process by which mature blood and immune cells are produced from hematopoietic stem and progenitor cells (HSCs and HSPCs). The last several decades of research have shed light on the origin of HSCs, as well as the heterogeneous pools of fetal progenitors that contribute to lifelong hematopoiesis. The overarching concept that hematopoiesis occurs in dynamic, overlapping waves throughout development, with each wave contributing to both continuous and developmentally limited cell types, has been solidified over the years. However, recent advances in our ability to track the production of hematopoietic cells in vivo have challenged several long-held dogmas on the origin and persistence of distinct hematopoietic cell types. In this review, we highlight emerging concepts in hematopoietic development and identify unanswered questions.

Citing Articles

The Impact of Sleep on Haematological Parameters in Firefighters.

Alves S, Silva F, Esteves F, Costa S, Slezakova K, Alves M Clocks Sleep. 2024; 6(3):291-311.

PMID: 39051311 PMC: 11270419. DOI: 10.3390/clockssleep6030021.

Immune Factors, Immune Cells and Inflammatory Diseases.

Ward A Int J Mol Sci. 2024; 25(4).

PMID: 38397094 PMC: 10889257. DOI: 10.3390/ijms25042417.

A CRISPR view of hematopoietic stem cells: Moving innovative bioengineering into the clinic.

Worthington A, Forsberg E Am J Hematol. 2022; 97(9):1226-1235.

PMID: 35560111 PMC: 9378712. DOI: 10.1002/ajh.26588.

Neutrophil Death in Myeloproliferative Neoplasms: Shedding More Light on Neutrophils as a Pathogenic Link to Chronic Inflammation.

Markovic D, Maslovaric I, Djikic D, cokic V Int J Mol Sci. 2022; 23(3).

PMID: 35163413 PMC: 8836089. DOI: 10.3390/ijms23031490.

IL7Rα, but not Flk2, is required for hematopoietic stem cell reconstitution of tissue-resident lymphoid cells.

Worthington A, Cool T, Poscablo D, Hussaini A, Beaudin A, Forsberg E Development. 2022; 149(8).

PMID: 35072209 PMC: 8917444. DOI: 10.1242/dev.200139.

References

Schulz C, Gomez Perdiguero E, Chorro L, Szabo-Rogers H, Cagnard N, Kierdorf K . A lineage of myeloid cells independent of Myb and hematopoietic stem cells. Science. 2012; 336(6077):86-90. DOI: 10.1126/science.1219179. View

Kim I, Saunders T, Morrison S . Sox17 dependence distinguishes the transcriptional regulation of fetal from adult hematopoietic stem cells. Cell. 2007; 130(3):470-83. PMC: 2577201. DOI: 10.1016/j.cell.2007.06.011. View

Lacaud G, Kouskoff V . Hemangioblast, hemogenic endothelium, and primitive versus definitive hematopoiesis. Exp Hematol. 2017; 49:19-24. DOI: 10.1016/j.exphem.2016.12.009. View

Yin J, Valin K, Dixon M, Leavenworth J . The Role of Microglia and Macrophages in CNS Homeostasis, Autoimmunity, and Cancer. J Immunol Res. 2018; 2017:5150678. PMC: 5749282. DOI: 10.1155/2017/5150678. View

Oberlin E, El Hafny B, Petit-Cocault L, Souyri M . Definitive human and mouse hematopoiesis originates from the embryonic endothelium: a new class of HSCs based on VE-cadherin expression. Int J Dev Biol. 2010; 54(6-7):1165-73. DOI: 10.1387/ijdb.103121eo. View

Zhao Y, Zhou J, Liu D, Dong F, Cheng H, Wang W . ATF4 plays a pivotal role in the development of functional hematopoietic stem cells in mouse fetal liver. Blood. 2015; 126(21):2383-91. PMC: 4653766. DOI: 10.1182/blood-2015-03-633354. View

Rhodes K, Gekas C, Wang Y, Lux C, Francis C, Chan D . The emergence of hematopoietic stem cells is initiated in the placental vasculature in the absence of circulation. Cell Stem Cell. 2008; 2(3):252-63. PMC: 2888040. DOI: 10.1016/j.stem.2008.01.001. View

Sorokin S, Hoyt Jr R, Blunt D, McNelly N . Macrophage development: II. Early ontogeny of macrophage populations in brain, liver, and lungs of rat embryos as revealed by a lectin marker. Anat Rec. 1992; 232(4):527-50. DOI: 10.1002/ar.1092320410. View

Warren A, Colledge W, Carlton M, Evans M, Smith A, Rabbitts T . The oncogenic cysteine-rich LIM domain protein rbtn2 is essential for erythroid development. Cell. 1994; 78(1):45-57. DOI: 10.1016/0092-8674(94)90571-1. View

10.

Kissa K, Herbomel P . Blood stem cells emerge from aortic endothelium by a novel type of cell transition. Nature. 2010; 464(7285):112-5. DOI: 10.1038/nature08761. View

11.

Macaulay I, Svensson V, Labalette C, Ferreira L, Hamey F, Voet T . Single-Cell RNA-Sequencing Reveals a Continuous Spectrum of Differentiation in Hematopoietic Cells. Cell Rep. 2016; 14(4):966-977. PMC: 4742565. DOI: 10.1016/j.celrep.2015.12.082. View

12.

Yu V, Yusuf R, Oki T, Wu J, Saez B, Wang X . Epigenetic Memory Underlies Cell-Autonomous Heterogeneous Behavior of Hematopoietic Stem Cells. Cell. 2016; 167(5):1310-1322.e17. DOI: 10.1016/j.cell.2016.10.045. View

13.

Spangrude G, Heimfeld S, Weissman I . Purification and characterization of mouse hematopoietic stem cells. Science. 1988; 241(4861):58-62. DOI: 10.1126/science.2898810. View

14.

Medvinsky A, Rybtsov S, Taoudi S . Embryonic origin of the adult hematopoietic system: advances and questions. Development. 2011; 138(6):1017-31. DOI: 10.1242/dev.040998. View

15.

Shivdasani R, Mayer E, Orkin S . Absence of blood formation in mice lacking the T-cell leukaemia oncoprotein tal-1/SCL. Nature. 1995; 373(6513):432-4. DOI: 10.1038/373432a0. View

16.

Barber C, Montecino-Rodriguez E, Dorshkind K . Reduced production of B-1-specified common lymphoid progenitors results in diminished potential of adult marrow to generate B-1 cells. Proc Natl Acad Sci U S A. 2011; 108(33):13700-4. PMC: 3158209. DOI: 10.1073/pnas.1107172108. View

17.

Perah G, Feldman M . In vitro activation of the in vivo colony-forming units of the mouse yolk sac. J Cell Physiol. 1977; 91(2):193-9. DOI: 10.1002/jcp.1040910205. View

18.

Tober J, Yzaguirre A, Piwarzyk E, Speck N . Distinct temporal requirements for Runx1 in hematopoietic progenitors and stem cells. Development. 2013; 140(18):3765-76. PMC: 3754475. DOI: 10.1242/dev.094961. View

19.

Griffiths J, Scialdone A, Marioni J . Using single-cell genomics to understand developmental processes and cell fate decisions. Mol Syst Biol. 2018; 14(4):e8046. PMC: 5900446. DOI: 10.15252/msb.20178046. View

20.

Hoeffel G, Ginhoux F . Ontogeny of Tissue-Resident Macrophages. Front Immunol. 2015; 6:486. PMC: 4585135. DOI: 10.3389/fimmu.2015.00486. View