Induction of an Antigen-specific, CD1-restricted Cytotoxic T Lymphocyte Response In Vivo

Overview

Journal J Exp Med

Specialties Allergy & Immunology
General Medicine

Date 1998 Mar 21

PMID 9449723

Citations 10

Authors

D J Lee

A Abeyratne

D A Carson

M Corr

Affiliations

Soon will be listed here.

Abstract

The majority of T cell responses are restricted to peptide antigens bound by polymorphic major histocompatibility complex (MHC) molecules. However, peptide antigens can be presented to T cells by murine non-MHC-encoded CD1d (mCD1) molecules, and human T cell lines specific for nonpeptide antigens presented on CD1 isoforms have been identified. It is shown here that antigen-specific, mCD1-restricted lymphocytes can be generated in vivo by immunizing mice with a combination of plasmids encoding chicken ovalbumin, murine CD1d, and costimulatory molecules. Splenocytes from immunized mice have CD1d-restricted, MHC- unrestricted, ovalbumin-specific cytolytic activity that can be inhibited by anti-CD1 antibodies as well as a competing CD1-binding peptide. These results suggest a physiologic role for murine CD1d to present exogenous protein antigens.

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References

Lafferty K, Cunningham A . A new analysis of allogeneic interactions. Aust J Exp Biol Med Sci. 1975; 53(1):27-42. DOI: 10.1038/icb.1975.3. View

Bretscher P, Cohn M . A theory of self-nonself discrimination. Science. 1970; 169(3950):1042-9. DOI: 10.1126/science.169.3950.1042. View

Bradbury A, Belt K, Neri T, Milstein C, Calabi F . Mouse CD1 is distinct from and co-exists with TL in the same thymus. EMBO J. 1988; 7(10):3081-6. PMC: 454695. DOI: 10.1002/j.1460-2075.1988.tb03173.x. View

Calabi F, Jarvis J, Martin L, Milstein C . Two classes of CD1 genes. Eur J Immunol. 1989; 19(2):285-92. DOI: 10.1002/eji.1830190211. View

Calabi F, Belt K, Yu C, Bradbury A, Mandy W, Milstein C . The rabbit CD1 and the evolutionary conservation of the CD1 gene family. Immunogenetics. 1989; 30(5):370-7. DOI: 10.1007/BF02425277. View

Balk S, Bleicher P, Terhorst C . Isolation and expression of cDNA encoding the murine homologues of CD1. J Immunol. 1991; 146(2):768-74. View

Peters P, Neefjes J, Oorschot V, Ploegh H, Geuze H . Segregation of MHC class II molecules from MHC class I molecules in the Golgi complex for transport to lysosomal compartments. Nature. 1991; 349(6311):669-76. DOI: 10.1038/349669a0. View

Porcelli S, Morita C, Brenner M . CD1b restricts the response of human CD4-8- T lymphocytes to a microbial antigen. Nature. 1992; 360(6404):593-7. DOI: 10.1038/360593a0. View

Schwartz R . Costimulation of T lymphocytes: the role of CD28, CTLA-4, and B7/BB1 in interleukin-2 production and immunotherapy. Cell. 1992; 71(7):1065-8. DOI: 10.1016/s0092-8674(05)80055-8. View

10.

Yoshimoto T, Paul W . CD4pos, NK1.1pos T cells promptly produce interleukin 4 in response to in vivo challenge with anti-CD3. J Exp Med. 1994; 179(4):1285-95. PMC: 2191455. DOI: 10.1084/jem.179.4.1285. View

11.

Tulp A, Verwoerd D, Dobberstein B, Ploegh H, Pieters J . Isolation and characterization of the intracellular MHC class II compartment. Nature. 1994; 369(6476):120-6. DOI: 10.1038/369120a0. View

12.

Balk S, Burke S, Polischuk J, FRANTZ M, Yang L, Porcelli S . Beta 2-microglobulin-independent MHC class Ib molecule expressed by human intestinal epithelium. Science. 1994; 265(5169):259-62. DOI: 10.1126/science.7517575. View

13.

Raz E, Carson D, Parker S, Parr T, Abai A, Aichinger G . Intradermal gene immunization: the possible role of DNA uptake in the induction of cellular immunity to viruses. Proc Natl Acad Sci U S A. 1994; 91(20):9519-23. PMC: 44844. DOI: 10.1073/pnas.91.20.9519. View

14.

Sanderson F, Kleijmeer M, Kelly A, Verwoerd D, Tulp A, Neefjes J . Accumulation of HLA-DM, a regulator of antigen presentation, in MHC class II compartments. Science. 1994; 266(5190):1566-9. DOI: 10.1126/science.7985027. View

15.

Corr M, Tighe H, Lee D, Dudler J, Trieu M, Brinson D . Costimulation provided by DNA immunization enhances antitumor immunity. J Immunol. 1997; 159(10):4999-5004. View

16.

Brenner M, Porcelli S . Antigen presentation: a balanced diet. Science. 1997; 277(5324):332. DOI: 10.1126/science.277.5324.332. View

17.

Beckman E, Porcelli S, Morita C, Behar S, Furlong S, Brenner M . Recognition of a lipid antigen by CD1-restricted alpha beta+ T cells. Nature. 1994; 372(6507):691-4. DOI: 10.1038/372691a0. View

18.

Hanau D, Fricker D, Bieber T, Bausinger H, Cazenave J, Donato L . CD1 expression is not affected by human peptide transporter deficiency. Hum Immunol. 1994; 41(1):61-8. DOI: 10.1016/0198-8859(94)90086-8. View

19.

Bendelac A, Lantz O, Quimby M, Yewdell J, Bennink J, Brutkiewicz R . CD1 recognition by mouse NK1+ T lymphocytes. Science. 1995; 268(5212):863-5. DOI: 10.1126/science.7538697. View

20.

Castano A, Tangri S, Miller J, Holcombe H, Jackson M, Huse W . Peptide binding and presentation by mouse CD1. Science. 1995; 269(5221):223-6. DOI: 10.1126/science.7542403. View