LBA Technique in the Detection of Chromosome Variants. II. Chromosomes Except for Those with Q Variants

Overview

Journal Hum Genet

Specialty Genetics

Date 1977 Oct 14

PMID 914279

Citations 6

Authors

Y NAKAGOME

S Oka

E Matsunaga

Affiliations

Soon will be listed here.

Abstract

In Part I of this communication, a technique (LBA) was described which used DNA replication in the evaluation of chromosome variants in man. It was shown that the method was very useful in the detection of variants in D- and G-group chromosomes. Results on pars 3 and 4 were also presented. In Part II, the rest of chromosomes were examined. In the evaluation of qh variants in 1, 9 and 16, the LBA technique proved itself to be a very effective implement. It was practically free of technical variables coherent with C-band technique and, therefore, it was possible to use the size of an euchromatic segment of a chromosome as a reference standard. LBA variants were observed in about 50% of the members of the remaining 12 pairs of chromosomes, i.e., 2, 5, 6, 7, 8, 10, 11, 12, 17, 18, 19, and 20.

Citing Articles

A new approach in the evaluation of chromosome variants in man. II. Pairs without Q or C (qh) variants.

Azumi J, NAKAGOME Y, Oka S, Matsunaga E Hum Genet. 1980; 55(1):75-9.

PMID: 7450758 DOI: 10.1007/BF00329130.

A new approach in the evaluation of chromosome variants in man, III. Pairs with established Q or C variable sites.

Oka S, NAKAGOME Y, Azumi J, Matsunaga E, Igarashi Y Hum Genet. 1980; 55(3):327-31.

PMID: 7203466 DOI: 10.1007/BF00290212.

Pericentric inversions. Problems and significance for clinical genetics.

Kaiser P Hum Genet. 1984; 68(1):1-47.

PMID: 6389316 DOI: 10.1007/BF00293869.

A rare heteromorphism of chromosome 20 and reproductive loss.

Romain D, Whyte S, Callen D, Eyre H J Med Genet. 1991; 28(7):477-8.

PMID: 1895318 PMC: 1016959. DOI: 10.1136/jmg.28.7.477.

Variation in chromosome 19.

Gardner H, Wood E J Med Genet. 1979; 16(1):79-80.

PMID: 469893 PMC: 1012788. DOI: 10.1136/jmg.16.1.79.

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