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A Mycobacterium Tuberculosis IS6110 Preferential Locus (ipl) for Insertion into the Genome

Overview
Journal J Clin Microbiol
Specialty Microbiology
Date 1997 Feb 1
PMID 9003621
Citations 45
Authors
Z Fang
K J Forbes
Affiliations
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Abstract

A 267-nucleotide Mycobacterium tuberculosis genomic sequence (ipl, the IS6110 preferential locus) which can harbor the insertion sequence IS6110 at six alternative locations has been identified in some three-quarters of the isolates tested. Only one IS6110 copy was observed at this locus in the ipl::IS6110(+)-containing isolates tested, and all insertions had the same orientation. The implications of this finding for IS6110 fingerprint typing methods is discussed in this work.

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In-depth Analysis of IS Genomic Variability in the Complex.

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Unexpected diversity of CRISPR unveils some evolutionary patterns of repeated sequences in Mycobacterium tuberculosis.

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Transposition mechanism, molecular characterization and evolution of IS6110, the specific evolutionary marker of Mycobacterium tuberculosis complex.

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Evolutionary Trends of the Transposase-Encoding Open Reading Frames A and B (orfA and orfB) of the Mycobacterial IS6110 Insertion Sequence.

Thabet S, Namouchi A, Mardassi H PLoS One. 2015; 10(6):e0130161.

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