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Biotechnology at Low Reynolds Numbers

Overview
Journal Biophys J
Publisher Cell Press
Specialty Biophysics
Date 1996 Dec 1
PMID 8968612
Citations 67
Authors
J P Brody
P Yager
R E Goldstein
R H Austin
Affiliations
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Abstract

The shrinking of liquid handling systems to the micron and submicron size range entails moving into the area of small Reynolds numbers. The fluid dynamics in this regime are very different from the macroscale. We present an intuitive explanation of how the different physics of small Reynolds numbers flow, along with microscopic sizes, can influence device design, and give examples from our own work using fluid flow in microfabricated devices designed for biological processing.

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References
1.
BOCQUET , BARRAT . Hydrodynamic boundary conditions and correlation functions of confined fluids. Phys Rev Lett. 1993; 70(18):2726-2729. DOI: 10.1103/PhysRevLett.70.2726. View
2.
Volkmuth W, Austin R . DNA electrophoresis in microlithographic arrays. Nature. 1992; 358(6387):600-2. DOI: 10.1038/358600a0. View
3.
Brody J, Han Y, Austin R, Bitensky M . Deformation and flow of red blood cells in a synthetic lattice: evidence for an active cytoskeleton. Biophys J. 1995; 68(6):2224-32. PMC: 1282133. DOI: 10.1016/S0006-3495(95)80443-1. View
4.
Wilding P, Shoffner M, Kricka L . PCR in a silicon microstructure. Clin Chem. 1994; 40(9):1815-8. View
5.
He , Kahanda , Wong . Roughness of wetting fluid invasion fronts in porous media. Phys Rev Lett. 1992; 69(26):3731-3734. DOI: 10.1103/PhysRevLett.69.3731. View