T Cell Response to Epstein-Barr Virus Transactivators in Chronic Rheumatoid Arthritis

Overview

Journal J Exp Med

Specialties Allergy & Immunology
General Medicine

Date 1996 Nov 1

PMID 8920867

Citations 54

Authors

E Scotet

M A Peyrat

A Moreau-Aubry

D Pinczon

A Lim

J Even

G Semana

J M Berthelot

R Breathnach

M Bonneville

E Houssaint

Affiliations

Soon will be listed here.

Abstract

Rheumatoid arthritis is a multistep disorder associated with autoimmune features of yet unknown etiology. Implication of viruses such as Epstein-Barr virus (EBV) in rheumatoid arthritis pathogenesis has been suspected on the basis of several indirect observations, but thus far, a direct link between EBV and rheumatoid arthritis has not been provided. Here we show that a large fraction of T cells infiltrating affected joints from a patient with chronic rheumatoid arthritis recognizes two EBV transactivators (BZLF1 and BMLF1) in a major histocompatibility complex-restricted fashion. Responses to these EBV antigens by synovial lymphocytes from several other chronic rheumatoid arthritis patients were readily detectable. Thus these results suggest a direct contribution of EBV to chronic rheumatoid arthritis pathogenesis. They also demonstrate for the first time the occurrence of T cell responses against EBV transactivating factors, which might be central in the control of virus reactivation.

Citing Articles

Epstein-Barr Viruses: Their Immune Evasion Strategies and Implications for Autoimmune Diseases.

Zhao Y, Zhang Q, Zhang B, Dai Y, Gao Y, Li C Int J Mol Sci. 2024; 25(15).

PMID: 39125729 PMC: 11311853. DOI: 10.3390/ijms25158160.

Antibody Cross-Reactivity in Auto-Immune Diseases.

Trier N, Houen G Int J Mol Sci. 2023; 24(17).

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Characteristics of the (Auto)Reactive T Cells in Rheumatoid Arthritis According to the Immune Epitope Database.

Carle C, Degboe Y, Ruyssen-Witrand A, Arleevskaya M, Clavel C, Renaudineau Y Int J Mol Sci. 2023; 24(5).

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Reconstitution of EBV-directed T cell immunity by adoptive transfer of peptide-stimulated T cells in a patient after allogeneic stem cell transplantation for AITL.

Lammoglia Cobo M, Ritter J, Gary R, Seitz V, Mautner J, Aigner M PLoS Pathog. 2022; 18(4):e1010206.

PMID: 35452490 PMC: 9067708. DOI: 10.1371/journal.ppat.1010206.

Role of Infections in the Pathogenesis of Rheumatoid Arthritis: Focus on Mycobacteria.

Bo M, Jasemi S, Uras G, Erre G, Passiu G, Sechi L Microorganisms. 2020; 8(10).

PMID: 32977590 PMC: 7598258. DOI: 10.3390/microorganisms8101459.

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