Epstein-Barr Virus in Systemic Lupus Erythematosus, Rheumatoid Arthritis and Multiple Sclerosis—association and Causation

Overview

Journal Viruses

Publisher MDPI

Specialty Microbiology

Date 2013 Jan 25

PMID 23342374

Citations 55

Authors

Andreas Lossius

Jorunn N Johansen

Oivind Torkildsen

Frode Vartdal

Trygve Holmoy

Affiliations

Soon will be listed here.

Abstract

Epidemiological data suggest that the Epstein-Barr virus (EBV) is associated with several autoimmune diseases, such as systemic lupus erythematosus, rheumatoid arthritis and multiple sclerosis. However, it is not clear whether EBV plays a role in the pathogenesis of these diseases, and if so, by which mechanisms the virus may contribute. In this review, we discuss possible viral and immunological mechanisms that might explain associations between EBV and autoimmune diseases and whether these associations represent causes or effects of inflammation and autoimmunity.

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