Expansion of Natural (NK1+) T Cells That Express Alpha Beta T Cell Receptors in Transporters Associated with Antigen Presentation-1 Null and Thymus Leukemia Antigen Positive Mice

Overview

Journal J Exp Med

Specialties Allergy & Immunology
General Medicine

Date 1996 Oct 1

PMID 8879233

Citations 12

Authors

S Joyce

I Negishi

A Boesteanu

A D DeSilva

P Sharma

M J Chorney

D Y Loh

L Van Kaer

Affiliations

Soon will be listed here.

Abstract

Thymic selection of natural killer-1+ natural T cells that express alpha beta T cell receptors requires a conserved beta 2-microglobulin-associated molecule, presumably CD1d, displayed by CD4+8+ thymocytes. Here we demonstrate that positive selection of natural T cells occurs independent of transporters associated with antigen presentation-1 (TAP-1) function. Moreover, natural T cells in TAP-1o/o mice are numerically expanded. Several H-2 class Ib molecules function in a TAP-independent manner, suggesting that if expressed in TAP-1o/o thymocytes, they could play a role in natural T cell development. Of these class Ib molecules, H-2TL is expressed by TAP-1o/o thymocytes. Moreover, we find that thymi of TL+ mice congenic or transgenic for H-2T18 also have a numerically expanded natural T cell repertoire compared with TL- mice. This expansion, as in TAP-1o/o thymi, is evident in each of the limited T cell receptor V beta chains expressed by natural T cells, suggesting that TL and CD1d impact similar repertoires. Thus TL, in addition to CD1d, plays a role in natural T cell development.

Citing Articles

Forming a complex with MHC class I molecules interferes with mouse CD1d functional expression.

Gourapura R, Khan M, Gallo R, Shaji D, Liu J, Brutkiewicz R PLoS One. 2013; 8(8):e72867.

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Invariant natural killer T cells in adipose tissue: novel regulators of immune-mediated metabolic disease.

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TL and CD8αα: Enigmatic partners in mucosal immunity.

Olivares-Villagomez D, Van Kaer L Immunol Lett. 2010; 134(1):1-6.

PMID: 20850477 PMC: 2967663. DOI: 10.1016/j.imlet.2010.09.004.

Thymus-leukemia antigen (TL) as a major histocompatibility complex (MHC) class Ib molecule and tumor-specific antigen.

Tsujimura K, Obata Y, Takahashi T Cancer Sci. 2004; 95(6):469-74.

PMID: 15182425 PMC: 11160087. DOI: 10.1111/j.1349-7006.2004.tb03234.x.

Intensive generation of NK1.1- extrathymic T cells in the liver by injection of bone marrow cells isolated from mice with a mutation of polymorphic major histocompatibility complex antigens.

Halder R, Kawamura T, Bannai M, Watanabe H, Kawamura H, Mannoor M Immunology. 2001; 102(4):450-9.

PMID: 11328379 PMC: 1783195. DOI: 10.1046/j.1365-2567.2001.01210.x.

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