IL-12 Unmasks Latent Autoimmune Disease in Resistant Mice

Overview

Journal J Exp Med

Specialties Allergy & Immunology
General Medicine

Date 1996 Aug 1

PMID 8786337

Citations 61

Authors

B M Segal

E M Shevach

Affiliations

Soon will be listed here.

Abstract

Inbred mice exhibit a spectrum of susceptibility to induction of experimental allergic encephalomyelitis (EAE). We have compared the immune responses of the susceptible SJL (H-2s) and resistant B10.S (H-2s) strains to determine factors other than the MHC background which control resistance/susceptibility to EAE. The resistance of the B10.S strain was found to be secondary to an antigen-specific defect in the generation of Th 1 cells that produce IFN gamma. This defect in IFN gamma production could be restored by exposure of the myelin basic protein (MBP)-reactive T cells to IL-12 with the subsequent induction of the ability to transfer EAE to naive recipients. These findings have important implications for the therapeutic use of IL-12 and IL-12 antagonists and may explain the association between relapses/exacerbation of autoimmune disease and infectious diseases.

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