Th1 and Th2 CD4+ T Cells in the Pathogenesis of Organ-specific Autoimmune Diseases

Overview

Journal Immunol Today

Specialty Allergy & Immunology

Date 1995 Jan 1

PMID 7880387

Citations 226

Authors

R S Liblau

S M Singer

H O McDevitt

Affiliations

Soon will be listed here.

Abstract

CD4+ T cells play a key role in regulating immune system function. When these regulatory processes go awry, organ-specific autoimmune diseases may develop. Here, Roland Liblau, Steven Singer and Hugh McDevitt explore the thesis that a particular subset of CD4+ T cells, namely T helper 1 (Th1) cells, contributes to the pathogenesis of organ-specific autoimmune diseases, while another subset, Th2 cells, prevents them.

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