The Uptake Mechanisms of Inflammation- and Infection-localizing Agents

Overview

Journal Eur J Nucl Med

Specialty Nuclear Medicine

Date 1996 Apr 1

PMID 8612669

Citations 10

Authors

W J Oyen

O C Boerman

C J van der Laken

R A Claessens

J W van der Meer

F H Corstens

Affiliations

Soon will be listed here.

Abstract

Over the past 30 years, a wide variety of radiopharmaceuticals have been proposed for the scintigraphic detection of inflammatory and infectious disease. All radiopharmaceuticals yield a functional image of a process placed somewhere in the cascade of reactions in inflammation, this being the common pathway of response to tissue injury. This paper discusses relevant aspects of the biodistribution, in vivo kinetics and mechanisms of uptake of both clinically used and experimental radiopharmaceuticals that have been proposed for the scintigraphic detection of focal inflammation and infection.

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