Polar/apolar Compounds Induce Leukemia Cell Differentiation by Modulating Cell-surface Potential

Overview

Journal Proc Natl Acad Sci U S A

Specialty Science

Date 1993 Jun 15

PMID 8516337

Citations 16

Authors

A Arcangeli

M Carla

M R Del Bene

A Becchetti

E Wanke

M Olivotto

Affiliations

Soon will be listed here.

Abstract

The mechanism of action of polar/apolar inducers of cell differentiation, such as dimethyl sulfoxide and hexamethylene-bisacetamide, is still obscure. In this paper evidence is provided that their effects on murine erythroleukemia cells are modulated by various extracellular cations as a precise function of the cation effects on membrane surface potential. The interfacial effects of the inducers were directly measured on the charged electrode, showing that both dimethyl sulfoxide and hexamethylene-bisacetamide, at the effective concentrations for cell differentiation and within the physiological range of charge density, adsorb at the charged surface and produce a potential shift. A linear correlation was found between this shift and the inducer effects on cell differentiation. Besides offering a different interpretation of the mechanism of action of the inducers, these findings indicate that surface potential has a signaling function. They may also be relevant to cancer treatments based on tumor-cell commitment to terminal differentiation.

Citing Articles

Planarian regeneration as a model of anatomical homeostasis: Recent progress in biophysical and computational approaches.

Levin M, Pietak A, Bischof J Semin Cell Dev Biol. 2018; 87:125-144.

PMID: 29635019 PMC: 6234102. DOI: 10.1016/j.semcdb.2018.04.003.

Bioelectric signaling in regeneration: Mechanisms of ionic controls of growth and form.

McLaughlin K, Levin M Dev Biol. 2018; 433(2):177-189.

PMID: 29291972 PMC: 5753428. DOI: 10.1016/j.ydbio.2017.08.032.

Drug-Loaded Polymeric Nanoparticles for Cancer Stem Cell Targeting.

Li B, Li Q, Mo J, Dai H Front Pharmacol. 2017; 8:51.

PMID: 28261093 PMC: 5306366. DOI: 10.3389/fphar.2017.00051.

Wnt/Beta-Catenin Signal Inhibitor HC-1 Sensitizes Oral Squamous Cell Carcinoma Cells to 5-Fluorouracil through Reduction of CD44-Positive Population.

Yokogi S, Tsubota T, Kanki K, Azumi J, Itaba N, Oka H Yonago Acta Med. 2016; 59(2):93-9.

PMID: 27493479 PMC: 4973014.

Use of genetically encoded, light-gated ion translocators to control tumorigenesis.

Chernet B, Adams D, Lobikin M, Levin M Oncotarget. 2016; 7(15):19575-88.

PMID: 26988909 PMC: 4991402. DOI: 10.18632/oncotarget.8036.

References

Hamill O, Marty A, Neher E, Sakmann B, Sigworth F . Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches. Pflugers Arch. 1981; 391(2):85-100. DOI: 10.1007/BF00656997. View

Orkin S, Harosi F, Leder P . Differentiation in erythroleukemic cells and their somatic hybrids. Proc Natl Acad Sci U S A. 1975; 72(1):98-102. PMC: 432248. DOI: 10.1073/pnas.72.1.98. View

Arcangeli A, Ricupero L, Olivotto M . Commitment to differentiation of murine erythroleukemia cells involves a modulated plasma membrane depolarization through Ca2+-activated K+ channels. J Cell Physiol. 1987; 132(3):387-400. DOI: 10.1002/jcp.1041320302. View

Edelman G . Cell adhesion and the molecular processes of morphogenesis. Annu Rev Biochem. 1985; 54:135-69. DOI: 10.1146/annurev.bi.54.070185.001031. View

Parsegian V . Possible modulation of reactions on the cell surface by changes in electrostatic potential that accompany cell contact. Ann N Y Acad Sci. 1974; 238:362-71. DOI: 10.1111/j.1749-6632.1974.tb26804.x. View

Groudine M, Weintraub H . Propagation of globin DNAase I-hypersensitive sites in absence of factors required for induction: a possible mechanism for determination. Cell. 1982; 30(1):131-9. DOI: 10.1016/0092-8674(82)90019-8. View

Friend C, Scher W, Holland J, Sato T . Hemoglobin synthesis in murine virus-induced leukemic cells in vitro: stimulation of erythroid differentiation by dimethyl sulfoxide. Proc Natl Acad Sci U S A. 1971; 68(2):378-82. PMC: 388942. DOI: 10.1073/pnas.68.2.378. View

Reuben R, Rifkind R, Marks P . Chemically induced murine erythroleukemic differentiation. Biochim Biophys Acta. 1980; 605(3):325-46. DOI: 10.1016/0304-419x(80)90015-3. View

Grassi F, Lux H . Voltage-dependent GABA-induced modulation of calcium currents in chick sensory neurons. Neurosci Lett. 1989; 105(1-2):113-9. DOI: 10.1016/0304-3940(89)90021-9. View

10.

Honig B, Hubbell W, Flewelling R . Electrostatic interactions in membranes and proteins. Annu Rev Biophys Biophys Chem. 1986; 15:163-93. DOI: 10.1146/annurev.bb.15.060186.001115. View

11.

Arcangeli A, Wanke E, Olivotto M, Camagni S, Ferroni A . Three types of ion channels are present on the plasma membrane of Friend erythroleukemia cells. Biochem Biophys Res Commun. 1987; 146(3):1450-7. DOI: 10.1016/0006-291x(87)90812-6. View

12.

Brown G . Electrostatic coupling between membrane proteins. FEBS Lett. 1990; 260(1):1-5. DOI: 10.1016/0014-5793(90)80051-j. View

13.

Gurdon J . Embryonic induction--molecular prospects. Development. 1987; 99(3):285-306. DOI: 10.1242/dev.99.3.285. View

14.

Arcangeli A, Del Bene M, Becchetti A, Wanke E, Olivotto M . Effects of inhibitors of ion-motive ATPases on the plasma membrane potential of murine erythroleukemia cells. J Membr Biol. 1992; 126(2):123-36. DOI: 10.1007/BF00231911. View

15.

Alitalo K, Vaheri A . Pericellular matrix in malignant transformation. Adv Cancer Res. 1982; 37:111-58. DOI: 10.1016/s0065-230x(08)60883-0. View

16.

Marks P, Sheffery M, Rifkind R . Induction of transformed cells to terminal differentiation and the modulation of gene expression. Cancer Res. 1987; 47(3):659-66. View

17.

Mosior M, McLaughlin S . Peptides that mimic the pseudosubstrate region of protein kinase C bind to acidic lipids in membranes. Biophys J. 1991; 60(1):149-59. PMC: 1260046. DOI: 10.1016/S0006-3495(91)82038-0. View

18.

McLaughlin S . The electrostatic properties of membranes. Annu Rev Biophys Biophys Chem. 1989; 18:113-36. DOI: 10.1146/annurev.bb.18.060189.000553. View

19.

Rovera G, Bonaiuto J . The phenotypes of variant clones of Friend mouse erythroleukemic cells resistant to dimethyl sulfoxide. Cancer Res. 1976; 36(11 Pt 1):4057-61. View

20.

FRANKENHAEUSER B, HODGKIN A . The action of calcium on the electrical properties of squid axons. J Physiol. 1957; 137(2):218-44. PMC: 1362975. DOI: 10.1113/jphysiol.1957.sp005808. View