Voltage-dependent GABA-induced Modulation of Calcium Currents in Chick Sensory Neurons

Overview

Journal Neurosci Lett

Specialty Neurology

Date 1989 Oct 23

PMID 2562057

Citations 64

Authors

F Grassi

H D Lux

Affiliations

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Abstract

Externally applied gamma-aminobutyric acid (GABA) quickly and reversibly reduces by 60% voltage activated Ca2+ currents in chick dorsal root ganglion cells. This action is antagonized by depolarization, with characteristic time and voltage requirements. Intracellular perfusion with guanosine 5'-O-(3-thiotriphosphate) (GTP gamma S) or guanosine 5'-O-(2-thiodiphosphate) (GDP beta S) mimicks and blocks the GABA effect, respectively. A 3-state model describing the reactions involved is proposed.

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