Cytokine Patterns in the Pathogenesis of Human Leishmaniasis

Overview

Journal J Clin Invest

Specialty General Medicine

Date 1993 Apr 1

PMID 8473490

Citations 107

Authors

C Pirmez

M Yamamura

K Uyemura

F Conceicao-Silva

R L Modlin

Affiliations

Soon will be listed here.

Abstract

The host response to infection appears to be regulated by specific patterns of local cytokine production. In the mouse, resistance to many pathogens including Leishmania is associated with a TH1 cytokine profile, IL-2 and IFN-gamma; whereas susceptibility to infection is associated with production of TH2 cytokines, IL-4, IL-5, and IL-10. To determine the cytokine patterns of the local immune response to Leishmania infection in humans, we used the polymerase chain reaction to compare cytokine mRNAs in biopsy specimens of American cutaneous leishmaniasis. In localized cutaneous leishmaniasis and the Montenegro delayed-type hypersensitivity reaction, type 1 cytokine mRNAs such as IL-2, IFN-gamma, and lymphotoxin were relatively predominant. In the chronic and destructive mucocutaneous form of leishmaniasis, there was a mixture of type 1 and type 2 cytokines, with a striking abundance of IL-4 mRNA in lesions. These results suggest that clinical course of infection with Leishmania braziliensis in man is associated with specific local patterns of cytokine production.

Citing Articles

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Cytokine and phenotypic cell profiles in human cutaneous leishmaniasis caused by Leishmania donovani.

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Opinion Article: NK Cells in Cutaneous Leishmaniasis: Protection or Damage?.

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