Three Inhibitors of Type 1 Human Immunodeficiency Virus Long Terminal Repeat-directed Gene Expression and Virus Replication

Overview

Journal Proc Natl Acad Sci U S A

Specialty Science

Date 1993 Mar 1

PMID 8446597

Citations 44

Authors

C J Li

L J Zhang

B J Dezube

C S Crumpacker

A B Pardee

Affiliations

Soon will be listed here.

Abstract

Transcription of type 1 human immunodeficiency virus (HIV-1) provirus is governed by the viral long terminal repeat (LTR). Drugs can block HIV-1 replication by inhibiting activity of its LTR. We report that topotecan, beta-lapachone, and curcumin are potent and selective inhibitors of HIV-1 LTR-directed gene expression, at concentrations that have minor effects on cells. At these concentrations, each drug inhibited p24 antigen production in cells either acutely or chronically infected with HIV-1. Their target is transcriptional function of the LTR.

Citing Articles

Curcumin derivative C210 induces Epstein-Barr virus lytic cycle and inhibits virion production by disrupting Hsp90 function.

Chen L, Guo X, Lin W, Huang Y, Zhuang S, Li Q Sci Rep. 2024; 14(1):26694.

PMID: 39496752 PMC: 11535535. DOI: 10.1038/s41598-024-77294-w.

Promising Potential of Curcumin and Related Compounds for Antiviral Drug Discovery.

Sharma A, Sharma T, Bhaskar R, Ola M, Sharma A, Chander Sharma P Med Chem. 2024; 20(6):597-612.

PMID: 38571348 DOI: 10.2174/0115734064277371240325105016.

In silico and in vitro prediction of new synthesized N-heterocyclic compounds as anti-SARS-CoV-2.

Hashem H, Ahmad S, Kumer A, El Bakri Y Sci Rep. 2024; 14(1):1152.

PMID: 38212472 PMC: 10784557. DOI: 10.1038/s41598-024-51443-7.

DNA topoisomerase 1 represses HIV-1 promoter activity through its interaction with a guanine quadruplex present in the LTR sequence.

Lista M, Jousset A, Cheng M, Saint-Andre V, Perrot E, Rodrigues M Retrovirology. 2023; 20(1):10.

PMID: 37254203 PMC: 10228017. DOI: 10.1186/s12977-023-00625-8.

A Camptothetin Analog, Topotecan, Promotes HIV Latency via Interference with HIV Transcription and RNA Splicing.

Mukim A, Smith D, Deshmukh S, Qazi A, Beliakova-Bethell N J Virol. 2023; 97(2):e0163022.

PMID: 36719238 PMC: 9973035. DOI: 10.1128/jvi.01630-22.

References

Hsu M, Schutt A, Holly M, Slice L, Sherman M, Richman D . Inhibition of HIV replication in acute and chronic infections in vitro by a Tat antagonist. Science. 1991; 254(5039):1799-802. DOI: 10.1126/science.1763331. View

Ammon H, Wahl M . Pharmacology of Curcuma longa. Planta Med. 1991; 57(1):1-7. DOI: 10.1055/s-2006-960004. View

Schuerch A, Wehrli W . beta-Lapachone, an inhibitor of oncornavirus reverse transcriptase and eukaryotic DNA polymerase-alpha. Inhibitory effect, thiol dependence and specificity. Eur J Biochem. 1978; 84(1):197-205. DOI: 10.1111/j.1432-1033.1978.tb12157.x. View

Shankar T, Shantha N, Ramesh H, Murthy I, Murthy V . Toxicity studies on turmeric (Curcuma longa): acute toxicity studies in rats, guineapigs & monkeys. Indian J Exp Biol. 1980; 18(1):73-5. View

Goncalves A, Vasconcellos M, Docampo R, CRUZ F, De Souza W, Leon W . Evaluation of the toxicity of 3-allyl-beta-lapachone against Trypanosoma cruzi bloodstream forms. Mol Biochem Parasitol. 1980; 1(3):167-76. DOI: 10.1016/0166-6851(80)90015-8. View

Maeda H . Neocarzinostatin in cancer chemotherapy (review). Anticancer Res. 1981; 1(3):175-86. View

Mosmann T . Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. J Immunol Methods. 1983; 65(1-2):55-63. DOI: 10.1016/0022-1759(83)90303-4. View

SCHMIDT-RUPPIN K, Wehrli W, Schuerch A, Wasley J . beta-Lapachone: synthesis of derivatives and activities in tumor models. J Med Chem. 1984; 27(8):990-4. DOI: 10.1021/jm00374a010. View

Herbomel P, Bourachot B, Yaniv M . Two distinct enhancers with different cell specificities coexist in the regulatory region of polyoma. Cell. 1984; 39(3 Pt 2):653-62. DOI: 10.1016/0092-8674(84)90472-0. View

10.

Satoskar R, Shah S, Shenoy S . Evaluation of anti-inflammatory property of curcumin (diferuloyl methane) in patients with postoperative inflammation. Int J Clin Pharmacol Ther Toxicol. 1986; 24(12):651-4. View

11.

Nabel G, Rice S, Knipe D, Baltimore D . Alternative mechanisms for activation of human immunodeficiency virus enhancer in T cells. Science. 1988; 239(4845):1299-302. DOI: 10.1126/science.2830675. View

12.

Lahdevirta J, Maury C, Teppo A, Repo H . Elevated levels of circulating cachectin/tumor necrosis factor in patients with acquired immunodeficiency syndrome. Am J Med. 1988; 85(3):289-91. DOI: 10.1016/0002-9343(88)90576-1. View

13.

Brenner D, Ohara M, Angel P, Chojkier M, Karin M . Prolonged activation of jun and collagenase genes by tumour necrosis factor-alpha. Nature. 1989; 337(6208):661-3. DOI: 10.1038/337661a0. View

14.

Folks T, Clouse K, Justement J, Rabson A, Duh E, Kehrl J . Tumor necrosis factor alpha induces expression of human immunodeficiency virus in a chronically infected T-cell clone. Proc Natl Acad Sci U S A. 1989; 86(7):2365-8. PMC: 286913. DOI: 10.1073/pnas.86.7.2365. View

15.

Griffin G, Leung K, Folks T, Kunkel S, Nabel G . Activation of HIV gene expression during monocyte differentiation by induction of NF-kappa B. Nature. 1989; 339(6219):70-3. DOI: 10.1038/339070a0. View

16.

Boothman D, Pardee A . Inhibition of radiation-induced neoplastic transformation by beta-lapachone. Proc Natl Acad Sci U S A. 1989; 86(13):4963-7. PMC: 297536. DOI: 10.1073/pnas.86.13.4963. View

17.

Cullen B, Greene W . Regulatory pathways governing HIV-1 replication. Cell. 1989; 58(3):423-6. DOI: 10.1016/0092-8674(89)90420-0. View

18.

Roederer M, Staal F, Raju P, Ela S, Herzenberg L . Cytokine-stimulated human immunodeficiency virus replication is inhibited by N-acetyl-L-cysteine. Proc Natl Acad Sci U S A. 1990; 87(12):4884-8. PMC: 54223. DOI: 10.1073/pnas.87.12.4884. View

19.

Mitsuya H, Yarchoan R, Broder S . Molecular targets for AIDS therapy. Science. 1990; 249(4976):1533-44. DOI: 10.1126/science.1699273. View

20.

Priel E, Showalter S, Roberts M, Oroszlan S, Segal S, Aboud M . Topoisomerase I activity associated with human immunodeficiency virus (HIV) particles and equine infectious anemia virus core. EMBO J. 1990; 9(12):4167-72. PMC: 552192. DOI: 10.1002/j.1460-2075.1990.tb07640.x. View