Curcumin Modulates Cellular AP-1, NF-kB, and HPV16 E6 Proteins in Oral Cancer

Overview

Journal Ecancermedicalscience

Specialty Oncology

Date 2015 May 2

PMID 25932049

Citations 35

Authors

Alok Mishra

Rakesh Kumar

Abhishek Tyagi

Indu Kohaar

Suresh Hedau

Alok C Bharti

Subhodeep Sarker

Dipankar Dey

Daman Saluja

Bhudev Das

Affiliations

Soon will be listed here.

Abstract

In this study, we investigated the effects of the natural antioxidant curcumin on the HPV16-positive oral carcinoma cell line 93VU147T and demonstrated that curcumin is not only a potent inhibitor for the activity of host nuclear transcription factors AP-1 and NF-kB but it also selectively suppresses transcription of the HPV16/E6 oncogene during the carcinogenic process in oral cancer cells. This study suggests a therapeutic potential of curcumin for high-risk human papilloma virus (HPV)-infected oral cancers.

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