Curcumae Rhizoma: A Botanical Drug Against Infectious Diseases

Overview

Journal Front Pharmacol

Date 2023 Jan 27

PMID 36703758

Authors

Ying-Qi Wu

Tong Tong

Affiliations

Soon will be listed here.

Abstract

Curcumae Rhizoma is the dry rhizome coming from Curcuma longa L. which grow widely in tropical south and southwest Asia. It has been used to treat conditions such as dermatoses, infections, stress, and depression. Moreover, in China, Curcumae Rhizoma and its active constituents have been made into different pharmaceutical preparations. Growing evidence suggests that these preparations can exert antioxidant, anti-inflammatory, and anti-cancer effects, which may play crucial roles in the treatment of various diseases, including cancer, infectious-, autoimmune-, neurological-, and cardiovascular diseases, as well as diabetes. The anti-infective effect of Curcumae Rhizoma has become a popular field of research around the world, including for the treatment of COVID-19, influenza virus, hepatitis B virus, human immunodeficiency virus, and human papilloma virus, among others. In this paper, the basic characteristics of Curcumae Rhizoma and its active constituents are briefly introduced, and we also give an overview on their applications and mechanisms in infectious diseases.

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References

Li C, Zhang L, Dezube B, Crumpacker C, Pardee A . Three inhibitors of type 1 human immunodeficiency virus long terminal repeat-directed gene expression and virus replication. Proc Natl Acad Sci U S A. 1993; 90(5):1839-42. PMC: 45975. DOI: 10.1073/pnas.90.5.1839. View

Romoli J, Silva M, Pante G, Hoeltgebaum D, Castro J, da Rocha G . Anti-mycotoxigenic and antifungal activity of ginger, turmeric, thyme and rosemary essential oils in deoxynivalenol (DON) and zearalenone (ZEA) producing . Food Addit Contam Part A Chem Anal Control Expo Risk Assess. 2021; 39(2):362-372. DOI: 10.1080/19440049.2021.1996636. View

Wang Z, Yin C, Gao Y, Liao Z, Li Y, Wang W . Novel functionalized selenium nanowires as antibiotic adjuvants in multiple ways to overcome drug resistance of multidrug-resistant bacteria. Biomater Adv. 2022; 137:212815. DOI: 10.1016/j.bioadv.2022.212815. View

Yu W, Qin X, Zhang Y, Qiu P, Wang L, Zha W . Curcumin suppresses doxorubicin-induced cardiomyocyte pyroptosis via a PI3K/Akt/mTOR-dependent manner. Cardiovasc Diagn Ther. 2020; 10(4):752-769. PMC: 7487371. DOI: 10.21037/cdt-19-707. View

Sandur S, Pandey M, Sung B, Ahn K, Murakami A, Sethi G . Curcumin, demethoxycurcumin, bisdemethoxycurcumin, tetrahydrocurcumin and turmerones differentially regulate anti-inflammatory and anti-proliferative responses through a ROS-independent mechanism. Carcinogenesis. 2007; 28(8):1765-73. DOI: 10.1093/carcin/bgm123. View

Ozturk S . Demonstration of the efficacy of curcumin on carbapenem-resistant Pseudomonas aeruginosa with Galleria mellonella larvae model. Arch Microbiol. 2022; 204(8):524. DOI: 10.1007/s00203-022-03135-x. View

Kumari N, Kulkarni A, Lin X, McLean C, Ammosova T, Ivanov A . Inhibition of HIV-1 by curcumin A, a novel curcumin analog. Drug Des Devel Ther. 2015; 9:5051-60. PMC: 4562762. DOI: 10.2147/DDDT.S86558. View

Fu Y, Ho W, Kang N, Tsai M, Wu J, Huang L . Pharmaceutical Prospects of Curcuminoids for the Remedy of COVID-19: Truth or Myth. Front Pharmacol. 2022; 13:863082. PMC: 9047796. DOI: 10.3389/fphar.2022.863082. View

Kim H, Jang E, Kim S, Choi J, Lee N, Kim D . Preclinical Evaluation of and Antiviral Activities of KCT-01, a New Herbal Formula against Hepatitis B Virus. Evid Based Complement Alternat Med. 2018; 2018:1073509. PMC: 6057320. DOI: 10.1155/2018/1073509. View

10.

Li Y, Wang H, Wang H, Wu Y, Li Y, Guo F . Nine new sesquiterpenes from Curcuma wenyujin rhizomes. Fitoterapia. 2022; 158:105167. DOI: 10.1016/j.fitote.2022.105167. View

11.

Zheng D, Huang C, Huang H, Zhao Y, Khan M, Zhao H . Antibacterial Mechanism of Curcumin: A Review. Chem Biodivers. 2020; 17(8):e2000171. DOI: 10.1002/cbdv.202000171. View

12.

Singh M, Alka , Lee K, Kumar P, Kang S . Curcuma Turmeric Oil Enhanced Anti-Dermatophytic Drug Activity Against Candida albicans and Trichophyton mentagrophytes. Curr Drug Deliv. 2021; 18(10):1494-1504. DOI: 10.2174/1567201818666210729105220. View

13.

Bourne K, Bourne N, Reising S, Stanberry L . Plant products as topical microbicide candidates: assessment of in vitro and in vivo activity against herpes simplex virus type 2. Antiviral Res. 1999; 42(3):219-26. DOI: 10.1016/s0166-3542(99)00020-0. View

14.

Kamurai B, Mombeshora M, Mukanganyama S . Repurposing of Drugs for Antibacterial Activities on Selected ESKAPE Bacteria and . Int J Microbiol. 2020; 2020:8885338. PMC: 7542517. DOI: 10.1155/2020/8885338. View

15.

Chen T, Chen D, Wen H, Ou J, Chiou S, Chen J . Inhibition of enveloped viruses infectivity by curcumin. PLoS One. 2013; 8(5):e62482. PMC: 3641039. DOI: 10.1371/journal.pone.0062482. View

16.

Chen M, Wang S, Tan M, Wang Y . Applications of nanoparticles in herbal medicine: zedoary turmeric oil and its active compound β-elemene. Am J Chin Med. 2011; 39(6):1093-102. DOI: 10.1142/S0192415X11009421. View

17.

Aggarwal B, Sung B . Pharmacological basis for the role of curcumin in chronic diseases: an age-old spice with modern targets. Trends Pharmacol Sci. 2008; 30(2):85-94. DOI: 10.1016/j.tips.2008.11.002. View

18.

Nabel G, Rice S, Knipe D, Baltimore D . Alternative mechanisms for activation of human immunodeficiency virus enhancer in T cells. Science. 1988; 239(4845):1299-302. DOI: 10.1126/science.2830675. View

19.

Ti H, Mai Z, Wang Z, Zhang W, Xiao M, Yang Z . Bisabolane-type sesquiterpenoids from L. exert anti-influenza and anti-inflammatory activities through NF-κB/MAPK and RIG-1/STAT1/2 signaling pathways. Food Funct. 2021; 12(15):6697-6711. DOI: 10.1039/d1fo01212f. View

20.

Li L, Xie Q, Bian G, Zhang B, Wang M, Wang Y . Anti-H1N1 viral activity of three main active ingredients from zedoary oil. Fitoterapia. 2020; 142:104489. DOI: 10.1016/j.fitote.2020.104489. View