The Mouse Mammary Tumor Virus Envelope Gene Product is Required for Superantigen Presentation to T Cells

Overview

Journal J Exp Med

Specialties Allergy & Immunology
General Medicine

Date 1994 Feb 1

PMID 8294859

Citations 24

Authors

T V Golovkina

A Chervonsky

J A Prescott

C A Janeway Jr

S R Ross

Affiliations

Soon will be listed here.

Abstract

Transgenic mice expressing either the mouse mammary tumor virus (MMTV) superantigen gene (sag) alone or in combination with the viral envelope genes (env) (LEL), or all of the viral genes (gag, pol, env, and sag) (HYB PRO), deleted V beta 14+ T cells from their immune repertoire. However, only LEL or HYB PRO transgenic antigen-presenting cells were capable of stimulating a proliferative response from nontransgenic primary T cells or interleukin 2 production from a V beta 15-bearing T cell hybridoma. These T cell responses could be inhibited by a monospecific antibody directed against the MMTV gp52 cell surface glycoprotein. These results indicate that the MMTV gp52 gene product participates in the presentation of superantigen to T cells, resulting in their stimulation, a requisite step in the MMTV infection pathway. Thus, gp52 could play a role in the transfer of virus between different subsets of lymphocytes.

Citing Articles

The endogenous locus and the immunoglobulin repertoire.

Beilinson H, Erickson S, Golovkina T Front Immunol. 2024; 15:1345467.

PMID: 38504980 PMC: 10948529. DOI: 10.3389/fimmu.2024.1345467.

A murine retrovirus co-Opts YB-1, a translational regulator and stress granule-associated protein, to facilitate virus assembly.

Bann D, Beyer A, Parent L J Virol. 2014; 88(8):4434-50.

PMID: 24501406 PMC: 3993753. DOI: 10.1128/JVI.02607-13.

Innate immune sensing of retroviral infection via Toll-like receptor 7 occurs upon viral entry.

Kane M, Case L, Wang C, Yurkovetskiy L, Dikiy S, Golovkina T Immunity. 2011; 35(1):135-45.

PMID: 21723157 PMC: 3519935. DOI: 10.1016/j.immuni.2011.05.011.

A novel block to mouse mammary tumor virus infection of lymphocytes in B10.BR mice.

Okeoma C, Shen M, Ross S J Virol. 2007; 82(3):1314-22.

PMID: 18003725 PMC: 2224452. DOI: 10.1128/JVI.01848-07.

Critical role of dendritic cells in mouse mammary tumor virus in vivo infection.

Courreges M, Burzyn D, Nepomnaschy I, Piazzon I, Ross S J Virol. 2007; 81(8):3769-77.

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