Mls--a Retrovirus Exploits the Immune System

Overview

Journal Immunol Today

Specialty Allergy & Immunology

Date 1991 Oct 1

PMID 1659830

Citations 58

Authors

H Acha-Orbea

E Palmer

Affiliations

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Abstract

The identity of minor lymphocytes stimulating (Mls) antigens, endogenous superantigens that can activate, or induce the deletion of, large portions of the T-cell repertoire, has recently been revealed: they are encoded by mouse mammary tumor viruses (MMTV) that have integrated into the germ line as DNA proviruses. As Hans Acha-Orbea and Ed Palmer point out, Mls-mediated modulation may be only the tip of the retrovirus iceberg; already murine leukemia virus (MuLV), with similar superantigen properties, has been discovered.

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