Urinary Catecholamine Excretion and Thyroid Hormone Blood Level in the Course of Severe Acute Brain Damage

Overview

Journal Eur J Intensive Care Med

Specialties Critical Care
General Medicine

Date 1975 Nov 1

PMID 812705

Citations 8

Authors

W Haider

H BENZER

G Krystof

F Lackner

O MAYRHOFER

K STEINBEREITHNER

K Irsigler

A Korn

W Schlick

H Binder

F Gerstenbrand

Affiliations

Soon will be listed here.

Abstract

Urinary catecholamine excretion and thyroid hormone blood level were studied in 16 patients following severe cerebral trauma. Increased excretion rates of epinephrine and norepinephrine were found. There was no significant difference in the catecholamine excretion when compared with generally traumatized patients. The relationships between catecholamine excretion, increased metabolic rates, and negative nitrogen balance indicate that in patients with a midbrain syndrome there exists an additional diencephalic metabolic factor, which leads to a rise in fat oxidation and perpetuation of catabolism. Early high caloric parenteral nutrition seems to inhibit the initial increase of catecholamine excretion and thus protects the body from an unnecessary breakdown of its own reserves. If the course is classified according to neurological stages, it can be shown that patients with a traumatic apallic syndrome in poor condition have a high increase of catecholamine excretion. Secretion of thyroid hormones is not influenced significantly by cerebral trauma.

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The activity of the sympathetic nervous system following severe head injury.

Hammerle A, Hackl J, Brucke T, Rumpl E, Hortnagl H Intensive Care Med. 1980; 6(3):169--7.

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Circadian profile of plasma cortisol and aldosterone in post-traumatic comatose patients under high-dose dexamethasone treatment.

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References

Zumtobel V . [Indications for parenteral administration of fats in surgical patients]. Infusionstherapie (1973). 1974; 1(7):531-5. View

CALDWELL Jr F, Osterholm J, SOWER N, Moyer C . Metabolic response to thermal trauma of normal and thyroprivic rats at three environmental temperatures. Ann Surg. 1959; 150:976-88. PMC: 1628990. DOI: 10.1097/00000658-195912000-00003. View

Haider W, BENZER H, Krystof G, Lackner F, MAYRHOFER O, STEINBEREITHNER K . Urinary catecholamine excretion and thyroid hormone blood level in the course of severe acute brain damage. Eur J Intensive Care Med. 1975; 1(3):115-23. DOI: 10.1007/BF00571658. View

SUTHERLAND E, Robison G . The role of cyclic-3',5'-AMP in responses to catecholamines and other hormones. Pharmacol Rev. 1966; 18(1):145-61. View

Jeejeebhoy K, Zohrab W, Langer B, Phillips M, Kuksis A, Anderson G . Total parenteral nutrition at home for 23 months, without complication, and with good rehabilitation. A study of technical and metabolic features. Gastroenterology. 1973; 65(5):811-20. View

Cuthbertson D, Tilstone W . Metabolism during the postinjury period. Adv Clin Chem. 1969; 12:1-55. DOI: 10.1016/s0065-2423(08)60257-7. View

STARLINGER H, Hawel W, Rutenfranz J . [Studies on the question of urinary catecholamine excretion as criterion of emotional stress under various environmental conditions. Vibration load, presentation of motion pictures and examination periods]. Int Z Angew Physiol. 1969; 27(1):1-14. View

WADSTROM L . Plasma lipids and surgical trauma; a methodologic experimental and clinical study. Acta Chir Scand Suppl. 1959; 116(Supp 238):1-19. View

Goodall M, Stone C, HAYNES Jr B . Urinary output of adrenaline and noradrenaline in severe thermal burns. Ann Surg. 1957; 145(4):479-87. PMC: 1465560. DOI: 10.1097/00000658-195704000-00004. View

10.

Challoner D, Steinberg D . Oxidative metabolism of myocardium as influenced by fatty acids and epinephrine. Am J Physiol. 1966; 211(4):97-902. DOI: 10.1152/ajplegacy.1966.211.4.897. View

11.

Carlson L . DEPOSITION, MOBILIZATION AND UTILIZATION OF FAT.A SCHEMATIC SURVEY. Acta Chir Scand Suppl. 1964; 325:SUPPL 325:5-13. View

12.

HAVEL R, Carlson L, EKELUND L, Holmgren A . STUDIES ON THE RELATION BETWEEN MOBILIZATION OF FREE FATTY ACIDS AND ENERGY METABOLISM IN MAN: EFFECTS OF NOREPINEPHRINE AND NICOTINIC ACID. Metabolism. 1964; 13:1402-12. DOI: 10.1016/0026-0495(64)90034-4. View

13.

FRANKSSON C, GEMZELL C, VON EULER U . Cortical and medullary adrenal activity in surgical and allied conditions. J Clin Endocrinol Metab. 1954; 14(6):608-21. DOI: 10.1210/jcem-14-6-608. View

14.

Birke G, DUNER H, LILJEDAHL S, PERNOW B, Plantin L, TROELL L . Histamine, catechol amines and adrenocortical steroids in burns. Acta Chir Scand. 1958; 114(2):87-98. View

15.

VON EULER U, LISHAJKO F . Improved technique for the fluorimetric estimation of catecholamines. Acta Physiol Scand. 1961; 51:348-55. DOI: 10.1111/j.1748-1716.1961.tb02128.x. View

16.

Prakash R, Parmley W, Horvat M, Swan H . Serum cortisol, plasma free fatty acids, and urinary cathecholamines as indicators of complications in acute myocardial infarction. Circulation. 1972; 45(4):736-45. DOI: 10.1161/01.cir.45.4.736. View