Protein and Amino Acid Metabolism After Severe Cerebral Trauma

Overview

Journal Intensive Care Med

Specialty Critical Care

Date 1985 Jan 1

PMID 3930587

Citations 2

Authors

J Piek

C B Lumenta

W J Bock

Affiliations

Soon will be listed here.

Abstract

Fourteen patients (20-48 years) suffering from severe head injury were followed for changes in amino acid and protein metabolism during the first 8 days after trauma. All patients received a standardized intravenous nutrition containing 15.7 g of nitrogen per day and additional carbohydrates. Electrolytes, free water, and blood constituents were given as needed. Additional treatment included surgical decompression of space-occupying hematomas, high dose dexamethasone therapy, and controlled hyperventilation for at least 5 days. Gross changes of protein metabolism were observed particularly on the days 5 and 6. The duration and chronological sequence of these changes are different from those usually found in patients with multiple injuries.

Citing Articles

Pathologic metabolism: an exploratory study of the plasma metabolome of critical injury.

Peltz E, DAlessandro A, Moore E, Chin T, Silliman C, Sauaia A J Trauma Acute Care Surg. 2015; 78(4):742-51.

PMID: 25807403 PMC: 4375785. DOI: 10.1097/TA.0000000000000589.

Dexamethasone therapy and endogenous cortisol production in severe pediatric head injury.

Fanconi S, Kloti J, Meuli M, Zaugg H, ZACHMANN M Intensive Care Med. 1988; 14(2):163-6.

PMID: 3361022 DOI: 10.1007/BF00257471.

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