Pipemidic Acid, a New Antibacterial Agent Active Against Pseudomonas Aeruginosa: in Vitro Properties

Overview

Journal Antimicrob Agents Chemother

Publisher American Society for Microbiology

Specialty Pharmacology

Date 1975 Aug 1

PMID 810076

Citations 26

Authors

M Shimizu

Y Takase

S Nakamura

H Katae

A Minami

Affiliations

Soon will be listed here.

Abstract

Pipemidic acid, 8-ethyl-5,8-dihydro-5-oxo-2-(1-piperazinyl)-pyrido [2,3-d]pyrimidine-6-carboxylic acid, is a new derivative of piromidic acid. It is active against gram-negative bacteria including Pseudomonas aeruginosa as well as some gram-positive bacteria. Its potency is generally greater than that of piromidic acid and nalidixic acid. Cross-resistance is not observed between pipemidic acid and various antibiotics, and most of bacteria resistant to piromidic acid and nalidixic acid are moderately susceptible to pipemidic acid. The activity of pipemidic acid is scarcely affected by the addition of serum, sodium cholate, or change of medium pH, but is subject to the influence of inoculum size. Its action is bactericidal above minimal inhibitory concentrations.

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References

LESHER G, FROELICH E, GRUETT M, Bailey J, BRUNDAGE R . 1,8-NAPHTHYRIDINE DERIVATIVES. A NEW CLASS OF CHEMOTHERAPEUTIC AGENTS. J Med Pharm Chem. 1962; 5:1063-5. DOI: 10.1021/jm01240a021. View

Shimizu M, Nakamura S, Takase Y, Kurobe N . Pipemidic acid: absorption, distribution, and excretion. Antimicrob Agents Chemother. 1975; 7(4):441-6. PMC: 429159. DOI: 10.1128/AAC.7.4.441. View

Matsumoto J, Minami S . Pyrido(2,3-d)pyrimidine antibacterial agents. 3. 8-Alkyl- and 8-vinyl-5,8-dihydro-5-oxo-2-(1-piperazinyl)pyrido(2,3-d)pyrimidine-6-carboxylic acids and their derivatives. J Med Chem. 1975; 18(1):74-9. DOI: 10.1021/jm00235a017. View