The Nonpeptide Neurotensin Antagonist, SR 48692, Used As a Tool to Reveal Putative Neurotensin Receptor Subtypes

Overview

Journal Br J Pharmacol

Publisher Wiley

Specialty Pharmacology

Date 1994 Jun 1

PMID 8075852

Citations 21

Authors

I Dubuc

J Costentin

J.P. Terranova

M C Barnouin

P Soubrie

G Le Fur

W Rostene

P Kitabgi

Affiliations

Soon will be listed here.

Abstract

The nonpeptide neurotensin (NT) antagonist, SR 48692, was recently shown to inhibit NT binding to the cloned rat and human NT receptor and to antagonize NT effects in a variety of in vitro and in vivo assays. Here, we show that, in contrast to its antagonistic action on NT-induced hypomotility in the rat, SR 48692 failed to antagonize NT-induced hypothermia and analgesia in the mouse and rat. We suggest that these effects might be mediated through a subtype of SR 48692-insensitive NT receptor.

Citing Articles

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Zhang M, Feng Y, Qiu X, Chen T, Bai Y, Feng J Front Neural Circuits. 2022; 15:775215.

PMID: 35002634 PMC: 8740200. DOI: 10.3389/fncir.2021.775215.

The Role of Central Neurotensin in Regulating Feeding and Body Weight.

Ramirez-Virella J, Leinninger G Endocrinology. 2021; 162(5).

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Beneficial Effects of Neurotensin in Murine Model of Hapten-Induced Asthma.

Russjan E, Kaczynska K Int J Mol Sci. 2019; 20(20).

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High plasma neurotensin levels in children with Prader-Willi syndrome.

Butler M, Nelson T, Driscoll D, Manzardo A Am J Med Genet A. 2015; 167A(8):1773-8.

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Morphological evidence for a neurotensinergic periaqueductal gray-rostral ventromedial medulla-spinal dorsal horn descending pathway in rat.

Wang J, Zhang H, Feng Y, Meng H, Wu L, Wang W Front Neuroanat. 2014; 8:112.

PMID: 25346662 PMC: 4191475. DOI: 10.3389/fnana.2014.00112.

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