Gut-brain Peptides in Corticostriatal-limbic Circuitry and Alcohol Use Disorders

Overview

Journal Front Neurosci

Date 2014 Oct 4

PMID 25278825

Citations 15

Authors

Chelsea A Vadnie

Jun Hyun Park

Noha Abdel Gawad

Ada Man Choi Ho

David J Hinton

Doo-Sup Choi

Affiliations

Soon will be listed here.

Abstract

Peptides synthesized in endocrine cells in the gastrointestinal tract and neurons are traditionally considered regulators of metabolism, energy intake, and appetite. However, recent work has demonstrated that many of these peptides act on corticostriatal-limbic circuitry and, in turn, regulate addictive behaviors. Given that alcohol is a source of energy and an addictive substance, it is not surprising that increasing evidence supports a role for gut-brain peptides specifically in alcohol use disorders (AUD). In this review, we discuss the effects of several gut-brain peptides on alcohol-related behaviors and the potential mechanisms by which these gut-brain peptides may interfere with alcohol-induced changes in corticostriatal-limbic circuitry. This review provides a summary of current knowledge on gut-brain peptides focusing on five peptides: neurotensin, glucagon-like peptide 1, ghrelin, substance P, and neuropeptide Y. Our review will be helpful to develop novel therapeutic targets for AUD.

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