Differential Effects of Intra-accumbens and Systemic Amphetamine on Latent Inhibition Using an On-baseline, Within-subject Conditioned Suppression Paradigm

Overview

Journal Psychopharmacology (Berl)

Specialty Pharmacology

Date 1993 Jan 1

PMID 7870920

Citations 17

Authors

A S Killcross

T W Robbins

Affiliations

Soon will be listed here.

Abstract

Latent inhibition (LI) is a phenomenon in which repeated, non-reinforced presentation of a stimulus retards subsequent conditioning to that stimulus. Several recent experiments have suggested that LI is abolished following acute, low doses of amphetamine given during pre-exposure and conditioning, and this effect has been attributed to amphetamine-induced changes in dopamine levels in the nucleus accumbens. Experiments 1 and 2 examined the effects of two doses of intra-accumbens d-amphetamine (10 micrograms/microliters and 3 micrograms/microliters) on LI in an on-baseline, within-subject conditioned suppression paradigm. There was no effect of either dose on LI, but a significant disinhibition of conditioned suppression resulted in a retardation of learning. In experiment 3 the effects of a low dose of systemic d-amphetamine (0.5 mg/kg) on latent inhibition were examined. The results replicated the abolition of LI found in previous studies, and demonstrated enhanced post-shock suppression in amphetamine-treated animals. These data provide no evidence for the involvement of the mesolimbic dopamine system in LI.

Citing Articles

Competing contextual processes rely on the infralimbic and prelimbic medial prefrontal cortices in the rat.

George D, Killcross S, Haddon J Oxf Open Neurosci. 2024; 2:kvad003.

PMID: 38596235 PMC: 10913818. DOI: 10.1093/oons/kvad003.

Behavioral Biomarkers of Schizophrenia in High Drinker Rats: A Potential Endophenotype of Compulsive Neuropsychiatric Disorders.

Navarro S, Alvarez R, Colomina M, Sanchez-Santed F, Flores P, Moreno M Schizophr Bull. 2016; 43(4):778-787.

PMID: 27872269 PMC: 5472118. DOI: 10.1093/schbul/sbw141.

Rethinking the emotional brain.

LeDoux J Neuron. 2012; 73(4):653-76.

PMID: 22365542 PMC: 3625946. DOI: 10.1016/j.neuron.2012.02.004.

Pre-exposure enhances recovery of conditioned responding after extinction.

Rosenberg H, Holmes N, Harris J, Westbrook R Learn Behav. 2011; 39(3):212-23.

PMID: 21327608 DOI: 10.3758/s13420-011-0019-5.

Dopamine in nucleus accumbens: salience modulation in latent inhibition and overshadowing.

Nelson A, Thur K, Marsden C, Cassaday H J Psychopharmacol. 2011; 25(12):1649-60.

PMID: 21262855 PMC: 3267554. DOI: 10.1177/0269881110389211.

References

Baruch I, Hemsley D, Gray J . Differential performance of acute and chronic schizophrenics in a latent inhibition task. J Nerv Ment Dis. 1988; 176(10):598-606. DOI: 10.1097/00005053-198810000-00004. View

Creese I, Iversen S . The pharmacological and anatomical substrates of the amphetamine response in the rat. Brain Res. 1975; 83(3):419-36. DOI: 10.1016/0006-8993(75)90834-3. View

Robbins T, Cador M, Taylor J, Everitt B . Limbic-striatal interactions in reward-related processes. Neurosci Biobehav Rev. 1989; 13(2-3):155-62. DOI: 10.1016/s0149-7634(89)80025-9. View

Blanc G, Herve D, Simon H, Lisoprawski A, Glowinski J, Tassin J . Response to stress of mesocortico-frontal dopaminergic neurones in rats after long-term isolation. Nature. 1980; 284(5753):265-7. DOI: 10.1038/284265a0. View

Joseph M, Frith C, Waddington J . Dopaminergic mechanisms and cognitive deficit in schizophrenia. A neurobiological model. Psychopharmacology (Berl). 1979; 63(3):273-80. DOI: 10.1007/BF00433561. View

White N, Viaud M . Localized intracaudate dopamine D2 receptor activation during the post-training period improves memory for visual or olfactory conditioned emotional responses in rats. Behav Neural Biol. 1991; 55(3):255-69. DOI: 10.1016/0163-1047(91)90609-t. View

Lyon M, RANDRUP A . The dose-response effect of amphetamine upon avoidance behaviour in the rat seen as a function of increasing stereotypy. Psychopharmacologia. 1972; 23(4):334-47. DOI: 10.1007/BF00406736. View

Weiner I . Neural substrates of latent inhibition: the switching model. Psychol Bull. 1990; 108(3):442-61. DOI: 10.1037/0033-2909.108.3.442. View

Weiner I, Feldon J . Latent inhibition is not affected by acute or chronic administration of 6 mg/kg dl-amphetamine. Psychopharmacology (Berl). 1987; 91(3):345-51. DOI: 10.1007/BF00518189. View

10.

Taylor J, Robbins T . 6-Hydroxydopamine lesions of the nucleus accumbens, but not of the caudate nucleus, attenuate enhanced responding with reward-related stimuli produced by intra-accumbens d-amphetamine. Psychopharmacology (Berl). 1986; 90(3):390-7. DOI: 10.1007/BF00179197. View

11.

Groves P, Rebec G . Biochemistry and behavior: some central actions of amphetamine and antipsychotic drugs. Annu Rev Psychol. 1976; 27:91-127. DOI: 10.1146/annurev.ps.27.020176.000515. View

12.

Solomon P, Crider A, Winkelman J, Turi A, Kamer R, Kaplan L . Disrupted latent inhibition in the rat with chronic amphetamine or haloperidol-induced supersensitivity: relationship to schizophrenic attention disorder. Biol Psychiatry. 1981; 16(6):519-37. View

13.

Clark A, Feldon J, Rawlins J . Aspiration lesions of rat ventral hippocampus disinhibit responding in conditioned suppression or extinction, but spare latent inhibition and the partial reinforcement extinction effect. Neuroscience. 1992; 48(4):821-9. DOI: 10.1016/0306-4522(92)90270-c. View

14.

Pijnenburg A, Honig W, van der Heyden J, van Rossum J . Effects of chemical stimulation of the mesolimbic dopamine system upon locomotor activity. Eur J Pharmacol. 1976; 35(1):45-58. DOI: 10.1016/0014-2999(76)90299-5. View

15.

Lyness W, Friedle N, Moore K . Destruction of dopaminergic nerve terminals in nucleus accumbens: effect on d-amphetamine self-administration. Pharmacol Biochem Behav. 1979; 11(5):553-6. DOI: 10.1016/0091-3057(79)90040-6. View

16.

Louilot A, Le Moal M, Simon H . Opposite influences of dopaminergic pathways to the prefrontal cortex or the septum on the dopaminergic transmission in the nucleus accumbens. An in vivo voltammetric study. Neuroscience. 1989; 29(1):45-56. DOI: 10.1016/0306-4522(89)90331-x. View

17.

Robbins T, Roberts D, Koob G . Effects of d-amphetamine and apomorphine upon operant behavior and schedule-induced licking in rats with 6-hydroxydopamine-induced lesions of the nucleus accumbens. J Pharmacol Exp Ther. 1983; 224(3):662-73. View

18.

Cole B, Robbins T . Effects of 6-hydroxydopamine lesions of the nucleus accumbens septi on performance of a 5-choice serial reaction time task in rats: implications for theories of selective attention and arousal. Behav Brain Res. 1989; 33(2):165-79. DOI: 10.1016/s0166-4328(89)80048-8. View

19.

Weiner I, Feldon J, Katz Y . Facilitation of the expression but not the acquisition of latent inhibition by haloperidol in rats. Pharmacol Biochem Behav. 1987; 26(2):241-6. DOI: 10.1016/0091-3057(87)90112-2. View

20.

Barrett R, Leith N, RAY O . Permanent facilitation of avoidance behavior by d-amphetamine and scopolamine. Psychopharmacologia. 1972; 25(4):321-31. DOI: 10.1007/BF00421971. View