Antineoplastic Activity of Alkylphosphocholines (APC) in Human Breast Carcinomas in Vivo and in Vitro; Use of Liposomes

Overview

Journal Breast Cancer Res Treat

Specialty Oncology

Date 1994 Jan 1

PMID 7865855

Citations 3

Authors

I Fichtner

R Zeisig

H Naundorf

S Jungmann

D Arndt

G Asongwe

J A Double

M C Bibby

Affiliations

Soon will be listed here.

Abstract

This study examines the in vitro and in vivo activity of alkylphosphocholines (APC) in experimental human breast carcinomas. Three analogs, hexadecylphosphocholine (HPC), octadecylphosphocholine (OPC) and eicosanylphosphocholine (EPC) were investigated. Three hormone receptor negative cell lines were sensitive to all three APCs in vitro whereas the receptor positive MCF-7 line was more resistant. Sensitivity was seen in 4/6 hormone receptor negative tumors in vivo, with HPC being the most active analog. There were no antitumor effects in the four receptor positive models. The reasons for these differences in response between hormone receptor negative and -positive lines are not yet understood and require further study. Gastrointestinal toxicity and hemolysis, the major side effects of the APCs, were reduced by the use of liposomal preparations.

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