Destruction of Human Solid Tumors by Alkyl Lysophospholipids

Overview

Journal J Natl Cancer Inst

Publisher Oxford University Press

Specialty Oncology

Date 1980 Jun 1

PMID 6929370

Citations 16

Authors

M H Runge

R Andreesen

A Pfleiderer

P G MUNDER

Affiliations

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Abstract

Alkyl lysophospholipids (ALP) are synthetic analogs of the naturally occurring 2-lysophosphatidylcholine. The effect of ALP on the proliferation of 22 different gynecologic malignant tumors in humans was studied in vitro. ALP caused progressive death of tumor cells over 24-96 hours. In addition, tumor specimens from the tested human tumors were xenotransplanted into NMRI nude mice. ALP induced a highly significant retardation of the in vivo growing human tumors. Neither oral nor iv administration of these compounds caused any recognizable side effects.

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