Establishment and Characteristics of Two New Human Mammary Carcinoma Lines Serially Transplantable in Nude Mice

Overview

Journal J Cancer Res Clin Oncol

Specialty Oncology

Date 1993 Jan 1

PMID 8102371

Citations 6

Authors

H Naundorf

I Fichtner

G J Saul

W Haensch

B Buttner

Affiliations

Soon will be listed here.

Abstract

Two human mammary carcinomas of postmenopausal women were successfully transplanted into nude mice. Both tumours were classified as epidermal-growth-factor-, oestradiol- and progesterone-receptor-negative and c-erbB2-protein-positive. Histological studies of the primary tumours (4000 and 4151) revealed ductal invasive mammary carcinomas. In the first passages the precondition for the growth of breast carcinoma 4000 were pretreatments of the nude mice with oestradiol and peanut oil before transplantation. The mammary carcinomas 4000 and 4151 described here are suitable for in vivo testing of antineoplastic substances and for biological studies.

Citing Articles

Treatment of experimental brain metastasis with MTO-liposomes: impact of fluidity and LRP-targeting on the therapeutic result.

Orthmann A, Zeisig R, Suss R, Lorenz D, Lemm M, Fichtner I Pharm Res. 2012; 29(7):1949-59.

PMID: 22399388 DOI: 10.1007/s11095-012-0723-7.

Molecular cytogenetic analysis of breast cancer cell lines.

Davidson J, Gorringe K, Chin S, Orsetti B, Besret C, Courtay-Cahen C Br J Cancer. 2000; 83(10):1309-17.

PMID: 11044355 PMC: 2408781. DOI: 10.1054/bjoc.2000.1458.

Reconstitution of mammary gland development in vitro: requirement of c-met and c-erbB2 signaling for branching and alveolar morphogenesis.

Niemann C, Brinkmann V, Spitzer E, Hartmann G, Sachs M, Naundorf H J Cell Biol. 1998; 143(2):533-45.

PMID: 9786961 PMC: 2132838. DOI: 10.1083/jcb.143.2.533.

Relation of oestradiol-mediated growth stimulation with the expression of c-erbB-2 protein in xenotransplanted oestradiol-receptor-positive and -negative breast carcinomas.

Naundorf H, Parczyk K, Zschiesche W, Reinecke S, Buttner B, Saul G J Cancer Res Clin Oncol. 1996; 122(1):14-20.

PMID: 8543587 DOI: 10.1007/BF01203068.

Antineoplastic activity of alkylphosphocholines (APC) in human breast carcinomas in vivo and in vitro; use of liposomes.

Fichtner I, Zeisig R, Naundorf H, Jungmann S, Arndt D, Asongwe G Breast Cancer Res Treat. 1994; 32(3):269-79.

PMID: 7865855 DOI: 10.1007/BF00666004.

References

Haldane J, Hird V, Hughes C, Gullick W . c-erbB-2 oncogene expression in ovarian cancer. J Pathol. 1990; 162(3):231-7. DOI: 10.1002/path.1711620309. View

Slamon D, Clark G, Wong S, Levin W, Ullrich A, McGuire W . Human breast cancer: correlation of relapse and survival with amplification of the HER-2/neu oncogene. Science. 1987; 235(4785):177-82. DOI: 10.1126/science.3798106. View

Paik S . Expression of IGF-I and IGF-II mRNA in breast tissue. Breast Cancer Res Treat. 1992; 22(1):31-8. DOI: 10.1007/BF01833331. View

Yee D, Paik S, Lebovic G, Marcus R, Favoni R, Cullen K . Analysis of insulin-like growth factor I gene expression in malignancy: evidence for a paracrine role in human breast cancer. Mol Endocrinol. 1989; 3(3):509-17. DOI: 10.1210/mend-3-3-509. View

Enami J, Enami S, Koga M . Growth of normal and neoplastic mouse mammary epithelial cells in primary culture: stimulation by conditioned medium from mouse mammary fibroblasts. Gan. 1983; 74(6):845-53. View

Rose D, Connolly J . Stimulation of growth of human breast cancer cell lines in culture by linoleic acid. Biochem Biophys Res Commun. 1989; 164(1):277-83. DOI: 10.1016/0006-291x(89)91714-2. View

Winograd B, Boven E, Lobbezoo M, Pinedo H . Human tumor xenografts in the nude mouse and their value as test models in anticancer drug development (review). In Vivo. 1987; 1(1):1-13. View

GIOVANELLA B, Vardeman D, Williams L, Taylor D, De Ipolyi P, Greeff P . Heterotransplantation of human breast carcinomas in nude mice. Correlation between successful heterotransplants, poor prognosis and amplification of the HER-2/neu oncogene. Int J Cancer. 1991; 47(1):66-71. DOI: 10.1002/ijc.2910470113. View

Peles E, Bacus S, Koski R, Lu H, Wen D, Ogden S . Isolation of the neu/HER-2 stimulatory ligand: a 44 kd glycoprotein that induces differentiation of mammary tumor cells. Cell. 1992; 69(1):205-16. DOI: 10.1016/0092-8674(92)90131-u. View

10.

De Bortoli M, Dati C, Antoniotti S, Maggiora P, Sapei M . Hormonal regulation of c-erbB-2 oncogene expression in breast cancer cells. J Steroid Biochem Mol Biol. 1992; 43(1-3):21-5. DOI: 10.1016/0960-0760(92)90183-j. View

11.

Naundorf H, Fichtner I, Buttner B, Frege J . Establishment and characterization of a new human oestradiol- and progesterone-receptor-positive mammary carcinoma serially transplantable in nude mice. J Cancer Res Clin Oncol. 1992; 119(1):35-40. DOI: 10.1007/BF01209485. View

12.

Naundorf H, Arnold W . Breeding of nude mice under improved conventional conditions. Z Versuchstierkd. 1981; 23(2):77-9. View

13.

Lovekin C, Ellis I, Locker A, Robertson J, Bell J, Nicholson R . c-erbB-2 oncoprotein expression in primary and advanced breast cancer. Br J Cancer. 1991; 63(3):439-43. PMC: 1971868. DOI: 10.1038/bjc.1991.101. View

14.

Gullick W, Love S, Wright C, Barnes D, Gusterson B, Harris A . c-erbB-2 protein overexpression in breast cancer is a risk factor in patients with involved and uninvolved lymph nodes. Br J Cancer. 1991; 63(3):434-8. PMC: 1971853. DOI: 10.1038/bjc.1991.100. View

15.

van t Veer P, van Leer E, Rietdijk A, Kok F, Schouten E, Hermus R . Combination of dietary factors in relation to breast-cancer occurrence. Int J Cancer. 1991; 47(5):649-53. DOI: 10.1002/ijc.2910470503. View

16.

Marx D, Schauer A, Reiche C, May A, Ummenhofer L, Reles A . c-erbB2 expression in correlation to other biological parameters of breast cancer. J Cancer Res Clin Oncol. 1990; 116(1):15-20. DOI: 10.1007/BF01612634. View