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Evaluation of Antibiotic Efficacy Using Electron Microscopy: Morphological Effects of Guanylureido Cephalosporin, BL-P1654, and Carbenicillin on Escherichia Coli

Overview
Journal Antimicrob Agents Chemother
Publisher American Society for Microbiology
Specialty Pharmacology
Date 1976 Feb 1
PMID 773295
Citations 1
Authors
L F Ellis
D K Herron
D A Preston
L K Simmons
R A Schlegel
Affiliations
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Abstract

Early response of Escherichia coli to minimal inhibitory concentrations of 112883, BL-P1654, and carbenicillin was determined by [(14)C]leucine uptake and scanning electron microscopy morphology studies. [(14)C]leucine uptake was inhibited later by carbenicillin than by BL-P1654 or 112883. Cellular swelling at 30 min, septal region swelling, and lysis were the progressive morphological changes with BL-P1654 and 112883. Carbenicillin-treated cells showed septal region swelling, beaded chains, and lysis.

Citing Articles

Evaluation of antibiotic efficacy using electron microscopy: morphological effects of guanylureido cephalosporin, chlorobenzoylureido cephalosporin, BL-P1654, and carbenicillin on Pseudomonas aeruginosa.

Ellis L, Herron D, Preston D, Simmons L, Schlegel R Antimicrob Agents Chemother. 1976; 9(2):334-42.

PMID: 817659 PMC: 429523. DOI: 10.1128/AAC.9.2.334.

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