Role of Xanthine Oxidase and Eicosanoids in Development of Pancreatic Ischemia-reperfusion Injury

Overview

Journal Inflammation

Specialties Allergy & Immunology
Pathology

Date 1995 Aug 1

PMID 7558251

Citations 2

Authors

G Hotter

D Closa

E Gelpi

N Prats

J Rosello-Catafau

Affiliations

Soon will be listed here.

Abstract

The implication of different eicosanoids and oxygen free radicals in the development of pancreatic injury after an ischemia-reperfusion process has been evaluated. For this purpose we have compared the effect of allopurinol and indomethacin administration on the pancreatic levels of eicosanoids in a rat model of pancreatic ischemia-reperfusion. After 60 min of pancreatic ischemia and 2 h of reperfusion, significant increases in 6-keto-PGF1 alpha, PGE2, and LTB4 in pancreas tissue were detected. Allopurinol before the ischemic period reduced 6-keto-PGF1 alpha, PGE2, and LTB4 levels to the range of basal values, while prior indomethacin treatment significantly reduced 6-keto-PGF1 alpha and PGE2 levels, with LTB4 remaining unmodified. Increased postischemic plasma lipases were also significantly reduced by allopurinol to the range of sham-operated animals whereas indomethacin did not modify these levels. The data suggest a role for lipoxygenase metabolites in the development of pancreatic injury and the importance of the enzyme xanthine oxidase as an inductor of eicosanoid biosynthesis.

Citing Articles

Reperfusion injury and reactive oxygen species: The evolution of a concept.

Granger D, Kvietys P Redox Biol. 2015; 6:524-551.

PMID: 26484802 PMC: 4625011. DOI: 10.1016/j.redox.2015.08.020.

Oxygen free radicals and redox biology of organelles.

Moldovan L, Moldovan N Histochem Cell Biol. 2004; 122(4):395-412.

PMID: 15452718 DOI: 10.1007/s00418-004-0676-y.

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