The Role of Oxygen Free Radicals in Experimental Acute Pancreatitis in the Rat

Overview

Journal Int J Pancreatol

Specialty Gastroenterology

Date 1989 Sep 1

PMID 2480983

Citations 8

Authors

T Koiwai

H Oguchi

S Kawa

Y Yanagisawa

T Kobayashi

T Homma

Affiliations

Soon will be listed here.

Abstract

In order to elucidate the role of oxygen-derived free radicals in acute pancreatitis, scavengers and an inhibitor of production of these free radicals were administered to rats with experimentally-induced acute pancreatitis. Acute reflux pancreatitis was produced by the occlusion of the common bile duct (OCD). Catalase and superoxide dismutase (SOD) were used as scavengers, and allopurinol was used as an inhibitor of production of free radicals. Six h after surgery, serum amylase, lipase, and thiobarbituric acid (TBA) reactant levels were elevated significantly, and histological changes in the pancreas, consisting of edema, inflammatory cell infiltration, and necrosis, partially around the intralobular and interlobular ducts, developed in the control rats receiving no agent. However, serum lipase and amylase levels in the rats given each agent were significantly lower (p less than 0.05) than in the controls. The histological changes in the pancreas were less marked in agent-treated rats than in untreated rats. These results suggest that oxygen-derived free radicals participate in the development of acute pancreatitis.

Citing Articles

Oxygen radical formation does not have an impact in the treatment of severe acute experimental pancreatitis using free cellular hemoglobin.

Kleinhans H, Mann O, Schurr P, Kaifi J, Hansen B, Izbicki J World J Gastroenterol. 2006; 12(18):2914-8.

PMID: 16718818 PMC: 4087810. DOI: 10.3748/wjg.v12.i18.2914.

Cu/Zn-SOD in human pancreatic tissue and pancreatic juice.

Hausmann D, Porstmann T, Weber I, Hausmann S, DUMMLER W, LIEBE S Int J Pancreatol. 1998; 22(3):207-13.

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Tachykinins stimulate lipid peroxidation mediated by free radicals in gastrointestinal tract of rat.

Lordal M, Soder O, Hellstrom P Dig Dis Sci. 1997; 42(7):1524-9.

PMID: 9246058 DOI: 10.1023/a:1018835314834.

Effect of antioxidant treatment in rats with acute hemorrhagic pancreatitis.

Schoenberg M, Buchler M, Younes M, Kirchmayr R, Bruckner U, Beger H Dig Dis Sci. 1994; 39(5):1034-40.

PMID: 8174416 DOI: 10.1007/BF02087555.

Role of xanthine oxidase and eicosanoids in development of pancreatic ischemia-reperfusion injury.

Hotter G, Closa D, Gelpi E, Prats N, Rosello-Catafau J Inflammation. 1995; 19(4):469-78.

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