Spatial Discontinuities in Human Immunodeficiency Virus Type 1 Quasispecies Derived from Epidermal Langerhans Cells of a Patient with AIDS and Evidence for Double Infection

Overview

Journal J Virol

Publisher American Society for Microbiology

Date 1994 Aug 1

PMID 7545939

Citations 20

Authors

M Sala

G Zambruno

J P Vartanian

A Marconi

U Bertazzoni

S Wain-Hobson

Affiliations

Soon will be listed here.

Abstract

A nonhomogeneous spatial distribution of human immunodeficiency virus type 1 quasispecies was observed for epidermal Langerhans cells purified from skin patches taken from a patient with AIDS soon after death. Each patch presented a unique collection of sequences, distinct from those of juxtaposed patches or those derived from the other leg. Infection of Langerhans cells by virus from underlying T cells in the dermis might explain this partition. The analysis revealed the presence of two distinct cocirculating viral strains, indicating double infection.

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