S Wain-Hobson
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Explore the profile of S Wain-Hobson including associated specialties, affiliations and a list of published articles.
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122
Citations
3892
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Recent Articles
1.
Kostrzak A, Caval V, Escande M, Pliquet E, Thalmensi J, Bestetti T, et al.
Gene Ther
. 2016 Nov;
24(2):74-83.
PMID: 27858943
Human APOBEC3A (A3A) cytidine deaminase shows pro-apoptotic properties resulting from hypermutation of genomic DNA, induction of double-stranded DNA breaks (DSBs) and G1 cell cycle arrest. Given this, we evaluated the...
2.
Kostrzak A, Henry M, Demoyen P, Wain-Hobson S, Vartanian J
Gene Ther
. 2014 Oct;
22(1):96-103.
PMID: 25298040
The mouse is widely used as a model for DNA therapy and vaccination even though the efficiency of DNA delivery in higher mammals and humans is much less. The human...
3.
Suspene R, Caval V, Henry M, Bouzidi M, Wain-Hobson S, Vartanian J
Br J Cancer
. 2014 Apr;
110(10):2615-22.
PMID: 24691422
Background: The revolution in cancer genomics shows that the dominant mutations are CG->TA transitions. The sources of these mutations are probably two host cell cytidine deaminases APOBEC3A and APOBEC3B. The...
4.
Ezzikouri S, Kitab B, Rebbani K, Marchio A, Wain-Hobson S, Dejean A, et al.
J Viral Hepat
. 2013 Sep;
20(10):678-86.
PMID: 24010642
The cytidine deaminase apolipoprotein B mRNA editing catalytic subunit-3 (APOBEC3) induces G-to-A hypermutation in hepatitis B virus (HBV) genomes and operates as part of the innate antiviral immune system. We...
5.
Leh-Louis V, Wirth B, Despons L, Wain-Hobson S, Potier S, Souciet J
Nucleic Acids Res
. 2004 Apr;
32(7):2069-78.
PMID: 15087486
Multigene families are observed in all genomes sequenced so far and are the reflection of key evolutionary mechanisms. The DUP240 family, identified in Saccharomyces cerevisiae strain S288C, is composed of...
6.
Blancou P, Chenciner N, Cumont M, Wain-Hobson S, Hurtrel B, Cheynier R
Proc Natl Acad Sci U S A
. 2001 Nov;
98(23):13237-42.
PMID: 11687626
Despite vigorous cell-mediated immune responses to human and simian immunodeficiency viruses (HIV/SIV) the immune system is unable to clear latently infected resting T cells. These infected cells are reactivated by...
7.
Vartanian J, Henry M, Wain-Hobson S
Proc Natl Acad Sci U S A
. 2001 Nov;
98(23):13172-6.
PMID: 11687609
Hypermutagenic PCR has been used to simulate pseudogene evolution of the Escherichia coli R67 dihydrofolate reductase gene. Each time the most divergent clone was used as template for another round...
8.
Hale P, Makgoba M, Merson M, Quinn T, Richman D, Vella S, et al.
Nature
. 2001 Jul;
412(6844):272.
PMID: 11460135
No abstract available.
9.
Hale P, Makgoba M, Merson M, Quinn T, Richman D, Vella S, et al.
Nature
. 2001 Jul;
412(6844):271-2.
PMID: 11460133
No abstract available.
10.
Frost S, Dumaurier M, Wain-Hobson S, Brown A
Proc Natl Acad Sci U S A
. 2001 Jun;
98(12):6975-80.
PMID: 11381143
Most HIV replication occurs in solid lymphoid tissue, which has prominent architecture at the histological level, which separates groups of productively infected CD4(+) cells. Nevertheless, current population models of HIV...