Application of Markers of Collagen Metabolism in Serum and Synovial Fluid for Assessment of Disease Process in Patients with Rheumatoid Arthritis

Overview

Journal Ann Rheum Dis

Specialty Rheumatology

Date 1995 Nov 1

PMID 7492237

Citations 9

Authors

M Hakala

S Aman

R Luukkainen

L Risteli

M Kauppi

P Nieminen

J Risteli

Affiliations

Soon will be listed here.

Abstract

Objective: To assess the potential of markers of collagen metabolism to reflect disease processes in rheumatoid arthritis (RA).

Methods: Serum (S) and synovial fluid (SF) from 59 patients with RA, and a knee joint effusion and serum from 90 control subjects were studied with radioimmunoassays for the aminoterminal propeptides of type I and type III procollagens (PINP and PIIINP, respectively). The breakdown of type I collagen was quantified with a radioimmunoassay for the cross linked carboxyterminal telopeptide of type I collagen (ICTP).

Results: About 50% of the patients had increased S-ICTP and S-PIIINP values, whereas S-PINP was increased in only 20% of the patients. The mean SF:S ratios of these markers varied between 4 (for ICTP) and 340 (for PIIINP), indicating that markers of collagen metabolism are formed locally and then released into the circulation. SF-PINP and SF-PIIINP correlated with each other (rs = 0.86, p < 0.001) and with SF-ICTP (rs = 0.69, p < 0.001, and rs = 0.65, p < 0.001, respectively). SF-ICTP was clearly related to radiographic findings in the corresponding knee joint, patients with gross bone deformation having the greatest SF-ICTP concentrations. S-ICTP and S-PIIINP also correlated with conventional markers of disease activity, such as C reactive protein and joint swelling score.

Conclusion: Markers of collagen metabolism both in serum and synovial fluid can be measured to provide an assessment of disease process in patients with RA. ICTP and PIIINP are the most informative.

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References

Peel N, Eastell R, Russell G . Markers of bone and collagen breakdown in early inflammatory arthritis. Baillieres Clin Rheumatol. 1992; 6(2):351-72. DOI: 10.1016/s0950-3579(05)80179-7. View

McDonald J, Levick J . Evidence for simultaneous bidirectional fluid flux across synovial lining in knee joints of anaesthetized rabbits. Exp Physiol. 1992; 77(3):513-5. DOI: 10.1113/expphysiol.1992.sp003613. View

Kroger H, Risteli J, Risteli L, Penttila I, Alhava E . Serum osteocalcin and carboxyterminal propeptide of type I procollagen in rheumatoid arthritis. Ann Rheum Dis. 1993; 52(5):338-42. PMC: 1005046. DOI: 10.1136/ard.52.5.338. View

Hakala M, Risteli L, Manelius J, Nieminen P, Risteli J . Increased type I collagen degradation correlates with disease severity in rheumatoid arthritis. Ann Rheum Dis. 1993; 52(12):866-9. PMC: 1005217. DOI: 10.1136/ard.52.12.866. View

Poole A . Immunochemical markers of joint inflammation, skeletal damage and repair: where are we now?. Ann Rheum Dis. 1994; 53(1):3-5. PMC: 1005233. DOI: 10.1136/ard.53.1.3. View

Jensen L, Henriksen J, Olesen H, Risteli J, Lorenzen I . Lymphatic clearance of synovial fluid in conscious pigs: the aminoterminal propeptide of type III procollagen. Eur J Clin Invest. 1993; 23(12):778-84. DOI: 10.1111/j.1365-2362.1993.tb00731.x. View

Paimela L, Leirisalo-Repo M, Risteli L, Hakala M, Helve T, Risteli J . Type I collagen degradation product in serum of patients with early rheumatoid arthritis: relationship to disease activity and radiological progression in a 3-year follow-up. Br J Rheumatol. 1994; 33(11):1012-6. DOI: 10.1093/rheumatology/33.11.1012. View

Taylor A, Lueken S, Libanati C, Baylink D . Biochemical markers of bone turnover for the clinical assessment of bone metabolism. Rheum Dis Clin North Am. 1994; 20(3):589-607. View

Kotaniemi A, Isomaki H, Hakala M, Risteli L, Risteli J . Increased type I collagen degradation in early rheumatoid arthritis. J Rheumatol. 1994; 21(9):1593-6. View

10.

Ritchie D, Boyle J, McInnes J, Jasani M, Dalakos T, Grieveson P . Clinical studies with an articular index for the assessment of joint tenderness in patients with rheumatoid arthritis. Q J Med. 1968; 37(147):393-406. View

11.

Larsen A, Dale K, Eek M . Radiographic evaluation of rheumatoid arthritis and related conditions by standard reference films. Acta Radiol Diagn (Stockh). 1977; 18(4):481-91. DOI: 10.1177/028418517701800415. View

12.

Gressner A, Neu H . N-terminal procollagen peptide and beta 2-microglobulin in synovial fluids from inflammatory and non-inflammatory joint diseases. Clin Chim Acta. 1984; 141(2-3):241-5. DOI: 10.1016/0009-8981(84)90016-0. View

13.

Horslev-Petersen K, Bentsen K, Junker P, Lorenzen I . Serum amino-terminal type III procollagen peptide in rheumatoid arthritis. Relationship to disease activity, treatment, and development of joint erosions. Arthritis Rheum. 1986; 29(5):592-9. DOI: 10.1002/art.1780290503. View

14.

Gabriel S, Luthra H . Rheumatoid arthritis: can the long-term outcome be altered?. Mayo Clin Proc. 1988; 63(1):58-68. DOI: 10.1016/s0025-6196(12)62665-2. View

15.

Horslev-Petersen K, Bentsen K, Engstrom-Laurent A, Junker P, Halberg P, Lorenzen I . Serum amino terminal type III procollagen peptide and serum hyaluronan in rheumatoid arthritis: relation to clinical and serological parameters of inflammation during 8 and 24 months' treatment with levamisole, penicillamine, or azathioprine. Ann Rheum Dis. 1988; 47(2):116-26. PMC: 1003463. DOI: 10.1136/ard.47.2.116. View

16.

Arnett F, Edworthy S, Bloch D, McShane D, Fries J, Cooper N . The American Rheumatism Association 1987 revised criteria for the classification of rheumatoid arthritis. Arthritis Rheum. 1988; 31(3):315-24. DOI: 10.1002/art.1780310302. View

17.

Risteli J, Niemi S, Trivedi P, Maentausta O, Mowat A, Risteli L . Rapid equilibrium radioimmunoassay for the amino-terminal propeptide of human type III procollagen. Clin Chem. 1988; 34(4):715-8. View

18.

Horslev-Petersen K, Saxne T, Haar D, Thomsen B, Bentsen K, Junker P . The aminoterminal-type-III procollagen peptide and proteoglycans in serum and synovial fluid of patients with rheumatoid arthritis or reactive arthritis. Rheumatol Int. 1988; 8(1):1-9. DOI: 10.1007/BF00541343. View

19.

Sharp J . Radiologic assessment as an outcome measure in rheumatoid arthritis. Arthritis Rheum. 1989; 32(2):221-9. DOI: 10.1002/anr.1780320218. View

20.

Brower A . Use of the radiograph to measure the course of rheumatoid arthritis. The gold standard versus fool's gold. Arthritis Rheum. 1990; 33(3):316-24. DOI: 10.1002/art.1780330303. View