Increased Type I Collagen Degradation Correlates with Disease Severity in Rheumatoid Arthritis

Overview

Journal Ann Rheum Dis

Specialty Rheumatology

Date 1993 Dec 1

PMID 8311537

Citations 12

Authors

M Hakala

L Risteli

J Manelius

P Nieminen

J Risteli

Affiliations

Soon will be listed here.

Abstract

Objectives: To assess the extent and clinical significance of type I collagen degradation in rheumatoid arthritis (RA).

Methods: Serum samples from 90 consecutive patients with RA from a cross-sectional population based study and 90 age- and sex-matched controls were analysed with the new assay of cross-linked carboxyterminal telopeptide of type I collagen (ICTP).

Results: Patients with RA had significantly higher concentrations of ICTP than the controls. ICTP correlated strongly with measures of impairment in RA, such as the erosive state of joint disease (ES) (r = 0.57, p < 0.001) and Keitel function test (KFT) (r = 0.49, p < 0.001), and more weakly with various disease activity markers. When erythrocyte sedimentation rate (ESR), ES or KFT were used as indicators of disease severity among the patients with disease duration over five years, ICTP distinguished the more serious RA from milder cases.

Conclusions: Elevated serum concentrations of ICTP are common in RA and are associated with signs of aggressive disease.

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References

Brower A . Use of the radiograph to measure the course of rheumatoid arthritis. The gold standard versus fool's gold. Arthritis Rheum. 1990; 33(3):316-24. DOI: 10.1002/art.1780330303. View

Kushner I . C-reactive protein in rheumatology. Arthritis Rheum. 1991; 34(8):1065-8. DOI: 10.1002/art.1780340819. View

McCarthy C, Steinberg G, Agren M, Leahey D, Wyman E, Baran D . Quantifying bone loss from the proximal femur after total hip arthroplasty. J Bone Joint Surg Br. 1991; 73(5):774-8. DOI: 10.1302/0301-620X.73B5.1894664. View

Roodman G . Interleukin-6: an osteotropic factor?. J Bone Miner Res. 1992; 7(5):475-8. DOI: 10.1002/jbmr.5650070502. View

Elomaa I, Virkkunen P, Risteli L, Risteli J . Serum concentration of the cross-linked carboxyterminal telopeptide of type I collagen (ICTP) is a useful prognostic indicator in multiple myeloma. Br J Cancer. 1992; 66(2):337-41. PMC: 1977792. DOI: 10.1038/bjc.1992.266. View

Peel N, Eastell R, Russell G . Markers of bone and collagen breakdown in early inflammatory arthritis. Baillieres Clin Rheumatol. 1992; 6(2):351-72. DOI: 10.1016/s0950-3579(05)80179-7. View

Eriksen E, Charles P, Melsen F, Mosekilde L, Risteli L, Risteli J . Serum markers of type I collagen formation and degradation in metabolic bone disease: correlation with bone histomorphometry. J Bone Miner Res. 1993; 8(2):127-32. DOI: 10.1002/jbmr.5650080202. View

Risteli J, Elomaa I, Niemi S, Novamo A, Risteli L . Radioimmunoassay for the pyridinoline cross-linked carboxy-terminal telopeptide of type I collagen: a new serum marker of bone collagen degradation. Clin Chem. 1993; 39(4):635-40. View

Hakala M, Pollanen R, Nieminen P . The ARA 1987 revised criteria select patients with clinical rheumatoid arthritis from a population based cohort of subjects with chronic rheumatic diseases registered for drug reimbursement. J Rheumatol. 1993; 20(10):1674-8. View

10.

Ritchie D, Boyle J, McInnes J, Jasani M, Dalakos T, Grieveson P . Clinical studies with an articular index for the assessment of joint tenderness in patients with rheumatoid arthritis. Q J Med. 1968; 37(147):393-406. View

11.

Keitel W, Hoffmann H, Weber G, Krieger U . [Evaluation of the percentage of functional decrease of the joints using a motor function test in rheumatology]. Dtsch Gesundheitsw. 1971; 26(40):1901-3. View

12.

Eberl D, Fasching V, Rahlfs V, Schleyer I, Wolf R . Repeatability and objectivity of various measurements in rheumatoid arthritis. A comparative study. Arthritis Rheum. 1976; 19(6):1278-86. DOI: 10.1002/art.1780190608. View

13.

Larsen A, Dale K, Eek M . Radiographic evaluation of rheumatoid arthritis and related conditions by standard reference films. Acta Radiol Diagn (Stockh). 1977; 18(4):481-91. DOI: 10.1177/028418517701800415. View

14.

Hancock D, Atkinson P, Reed G, WRIGHT V . Femoral bone mass in patients with rheumatoid arthritis and osteoarthrosis. Rheumatol Rehabil. 1978; 17(2):65-71. DOI: 10.1093/rheumatology/17.2.65. View

15.

Luukkainen R . Chrysotherapy in rheumatoid arthritis with particular emphasis on the effect of chrysotherapy on radiographical changes and on the optimal time of initiation of therapy. Scand J Rheumatol Suppl. 1980; 34:1-56. View

16.

Gabriel S, Luthra H . Rheumatoid arthritis: can the long-term outcome be altered?. Mayo Clin Proc. 1988; 63(1):58-68. DOI: 10.1016/s0025-6196(12)62665-2. View

17.

Arnett F, Edworthy S, Bloch D, McShane D, Fries J, Cooper N . The American Rheumatism Association 1987 revised criteria for the classification of rheumatoid arthritis. Arthritis Rheum. 1988; 31(3):315-24. DOI: 10.1002/art.1780310302. View

18.

Seibel M, Duncan A, Robins S . Urinary hydroxy-pyridinium crosslinks provide indices of cartilage and bone involvement in arthritic diseases. J Rheumatol. 1989; 16(7):964-70. View

19.

Arend W, Dayer J . Cytokines and cytokine inhibitors or antagonists in rheumatoid arthritis. Arthritis Rheum. 1990; 33(3):305-15. DOI: 10.1002/art.1780330302. View