Elevated Levels of Serum Type I Collagen C-telopeptide in Patients with Rapidly Destructive Osteoarthritis of the Hip

Overview

Journal Int Orthop

Specialty Orthopedics

Date 2004 Dec 31

PMID 15625614

Citations 9

Authors

Christian E Berger

Andreas Kroner

Helmar Stiegler

Thomas Leitha

Alfred Engel

Affiliations

Soon will be listed here.

Abstract

We compared type I collagen degradation using serum cross-linking C-terminal telopeptide (ICTP) in 18 patients with rapidly destructive osteoarthrosis and in 20 patients with slowly progressive osteoarthrosis of the hip. The diagnosis was established by clinical examination and radiographic evaluation. Total hip arthroplasty was performed in all patients. Serum levels of ICTP, bone-specific alkaline phosphatase, osteocalcin and N-terminal propeptide were studied. Patients with rapidly destructive osteoarthrosis had higher mean (SD) serum ICTP levels than patients with slowly progressive osteoarthrosis [13.2 (5.6) versus 3.7 ng/ml (1.4), p=0.001] whereas no significant difference of all other markers was seen between the groups. Elevation of ICTP levels correlated significantly with decreased joint-space width assessed by radiographs of the hip (p=0.01). Our data suggest that rapidly destructive hip osteoarthrosis is associated with elevated serum ICTP levels, reflecting increased collagen type I degradation.

Citing Articles

Evaluating Biomarkers of Bone Health After an 8-Week Walking Program in Non-Ambulatory Stroke Survivors: A Pilot Study.

Alajam R, Alqahtani A, Moon S, Sarmento C, Smirnova I, Pang M J Clin Med. 2024; 13(21).

PMID: 39518593 PMC: 11547151. DOI: 10.3390/jcm13216453.

Rapidly Progressive Osteoarthritis of the Hip: A Prospective Study.

Montero Furelos L, De Castro Carrasco A, Cons Lamas S, Sanchez Sierra F, Caeiro-Rey J J Clin Med. 2024; 13(9).

PMID: 38730996 PMC: 11084505. DOI: 10.3390/jcm13092467.

Clinical monitoring in osteoarthritis: Biomarkers.

Kraus V, Karsdal M Osteoarthritis Cartilage. 2021; 30(9):1159-1173.

PMID: 34536529 PMC: 8924021. DOI: 10.1016/j.joca.2021.04.019.

Characterization of rapidly progressive osteoarthritis of the hip in its early stage.

Yasuda T, Matsunaga K, Hashimura T, Tsukamoto Y, Sueyoshi T, Ota S Eur J Rheumatol. 2020; 7(3):130-134.

PMID: 32384049 PMC: 7431352. DOI: 10.5152/eurjrheum.2020.19159.

Clinico-radiological diagnosis and grading of rapidly progressive osteoarthritis of the hip.

Zazgyva A, Gurzu S, Gergely I, Jung I, Roman C, Pop T Medicine (Baltimore). 2017; 96(12):e6395.

PMID: 28328832 PMC: 5371469. DOI: 10.1097/MD.0000000000006395.

References

Flik K, Vargas 3rd J . Rapidly destructive hip disease: a case report and review of the literature. Am J Orthop (Belle Mead NJ). 2000; 29(7):549-52. View

Delmas P . Biochemical markers of bone turnover in Paget's disease of bone. J Bone Miner Res. 1999; 14 Suppl 2:66-9. DOI: 10.1002/jbmr.5650140213. View

Laroche M, Moineuse C, Durroux R, Mazieres B, Puget J . Can ischemic hip disease cause rapidly destructive hip osteoarthritis? A case report. Joint Bone Spine. 2002; 69(1):76-80. DOI: 10.1016/s1297-319x(01)00346-3. View

Berger C, Kroner A, Thomas E, Kristen K, Ogris E, Engel A . Comparison of biochemical markers of bone metabolism in serum and femur aspirates. Clin Orthop Relat Res. 2002; (395):174-9. DOI: 10.1097/00003086-200202000-00019. View

Qvist P, Christgau S, Pedersen B, Schlemmer A, Christiansen C . Circadian variation in the serum concentration of C-terminal telopeptide of type I collagen (serum CTx): effects of gender, age, menopausal status, posture, daylight, serum cortisol, and fasting. Bone. 2002; 31(1):57-61. DOI: 10.1016/s8756-3282(02)00791-3. View

Piaggesi A, Rizzo L, Golia F, Costi D, Baccetti F, Ciaccio S . Biochemical and ultrasound tests for early diagnosis of active neuro-osteoarthropathy (NOA) of the diabetic foot. Diabetes Res Clin Pract. 2002; 58(1):1-9. DOI: 10.1016/s0168-8227(02)00097-9. View

Boutry N, Paul C, Leroy X, Fredoux D, Migaud H, Cotten A . Rapidly destructive osteoarthritis of the hip: MR imaging findings. AJR Am J Roentgenol. 2002; 179(3):657-63. DOI: 10.2214/ajr.179.3.1790657. View

Schneider U, Schmidt-Rohlfing B, Knopf U, Breusch S . Effects upon bone metabolism following total hip and total knee arthroplasty. Pathobiology. 2002; 70(1):26-33. DOI: 10.1159/000065999. View

Kotaniemi A, Risteli J, Aho K, Hakala M . Increased type I collagen degradation correlates with disease activity in reactive arthritis. Clin Exp Rheumatol. 2003; 21(1):95-8. View

10.

Garnero P, Ferreras M, Karsdal M, Nicamhlaoibh R, Risteli J, Borel O . The type I collagen fragments ICTP and CTX reveal distinct enzymatic pathways of bone collagen degradation. J Bone Miner Res. 2003; 18(5):859-67. DOI: 10.1359/jbmr.2003.18.5.859. View

11.

Wilkinson J, Hamer A, Rogers A, Stockley I, Eastell R . Bone mineral density and biochemical markers of bone turnover in aseptic loosening after total hip arthroplasty. J Orthop Res. 2003; 21(4):691-6. DOI: 10.1016/S0736-0266(02)00237-1. View

12.

Garnero P, Conrozier T, Christgau S, Mathieu P, Delmas P, Vignon E . Urinary type II collagen C-telopeptide levels are increased in patients with rapidly destructive hip osteoarthritis. Ann Rheum Dis. 2003; 62(10):939-43. PMC: 1754328. DOI: 10.1136/ard.62.10.939. View

13.

Harris W . Traumatic arthritis of the hip after dislocation and acetabular fractures: treatment by mold arthroplasty. An end-result study using a new method of result evaluation. J Bone Joint Surg Am. 1969; 51(4):737-55. View

14.

Postel M, Kerboull M . Total prosthetic replacement in rapidly destructive arthrosis of the hip joint. Clin Orthop Relat Res. 1970; 72:138-44. View

15.

Rosenberg Z, SHANKMAN S, STEINER G, Kastenbaum D, Norman A, LAZANSKY M . Rapid destructive osteoarthritis: clinical, radiographic, and pathologic features. Radiology. 1992; 182(1):213-6. DOI: 10.1148/radiology.182.1.1727284. View

16.

Komiya S, Inoue A, Sasaguri Y, Minamitani K, Morimatsu M . Rapidly destructive arthropathy of the hip. Studies on bone resorptive factors in joint fluid with a theory of pathogenesis. Clin Orthop Relat Res. 1992; (284):273-82. View

17.

Eriksen E, Charles P, Melsen F, Mosekilde L, Risteli L, Risteli J . Serum markers of type I collagen formation and degradation in metabolic bone disease: correlation with bone histomorphometry. J Bone Miner Res. 1993; 8(2):127-32. DOI: 10.1002/jbmr.5650080202. View

18.

Lequesne M . [Rapidly progressing destructive diseases of the hip]. Ann Radiol (Paris). 1993; 36(1):62-4. View

19.

Hakala M, Aman S, Luukkainen R, Risteli L, Kauppi M, Nieminen P . Application of markers of collagen metabolism in serum and synovial fluid for assessment of disease process in patients with rheumatoid arthritis. Ann Rheum Dis. 1995; 54(11):886-90. PMC: 1010038. DOI: 10.1136/ard.54.11.886. View

20.

Meneghello A, Franceschi E . [Destructive arthrosis of the hip. Natural history, pathogenesis, and radiographic features]. Radiol Med. 1996; 92(3):186-92. View