Isolation of a Highly Cytopathic Lentivirus from a Nondomestic Cat

Overview

Journal J Virol

Publisher American Society for Microbiology

Date 1995 Nov 1

PMID 7474172

Citations 10

Authors

M C Barr

L Zou

D L Holzschu

L Phillips

F W Scott

J W Casey

R J Avery

Affiliations

Soon will be listed here.

Abstract

A feline immunodeficiency virus-like virus (FIV-Oma) isolated from a Pallas' cat (Otocolobus manul) is highly cytopathic in CrFK cells, in contrast to the chronic, noncytolytic infection established by an FIV isolate from a domestic cat (FIV-Fca). The virions have typical lentivirus morphology, density, and magnesium-dependent reverse transcriptase activity. The major core protein is antigenically cross-reactive with that of FIV-Fca; however, FIV-Oma transcripts do not cross-hybridize with FIV-Fca. A conserved region of the FIV-Oma pol gene has 76 to 80% nucleic acid identify with the corresponding pol regions of other feline lentiviruses and 64 to 69% identity with those of human, ovine, and equine lentiviruses.

Citing Articles

Review and Perspectives on the Structure-Function Relationships of the Gag Subunits of Feline Immunodeficiency Virus.

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Feline immunodeficiency virus (FIV) in wild Pallas' cats.

Brown M, Munkhtsog B, Troyer J, Ross S, Sellers R, Fine A Vet Immunol Immunopathol. 2009; 134(1-2):90-5.

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Puma lentivirus is controlled in domestic cats after mucosal exposure in the absence of conventional indicators of immunity.

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