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High-affinity [3H]imipramine Binding in Rat Hypothalamus: Association with Uptake of Serotonin but Not of Norepinephrine

Overview
Journal Science
Specialty Science
Date 1980 Dec 5
PMID 7444441
Citations 45
Authors
S Z Langer
C Moret
R Raisman
M L Dubocovich
M Briley
Affiliations
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Abstract

Inhibition of the binding of [3H]imipramine and inhibition of the uptake of [3H]serotonin and [3H]norepinephrine by a series of antidepressants and other drugs were studied in the rat hypothalamus. No correlation was found between the potencies of these drugs for the inhibition of [3H]imipramine binding and the inhibition of [3H]norepinephrine uptake. There was, however, a highly significant correlation between the potencies of these drugs for the inhibition of [3H]serotonin uptake. These results suggest that high-affinity [3H]imipramine binding might be associated with the mechanism of serotonin uptake in the brain.

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