High-affinity 3H-imipramine Binding in Platelets from Untreated and Treated Depressed Patients Compared to Healthy Volunteers

Overview

Journal Psychopharmacology (Berl)

Specialty Pharmacology

Date 1981 Jan 1

PMID 6803282

Citations 10

Authors

R Raisman

D Sechter

M S Briley

E Zarifian

S Z Langer

Affiliations

Soon will be listed here.

Abstract

Specific high-affinity binding of 3H-imipramine to human platelets possesses very similar characteristics to the sites previously described in animal and human brains. In a study comparing the binding of 3H-imipramine in platelets obtained from 39 control volunteers with 37 hospitalized, untreated, severely depressed patients, the maximal binding of 3H-imipramine was found to be significantly lower in the depressed population. There were no differences in the KD values. After 7-15 days of treatment with tricyclic anti-depressant drugs, there was an improvement in the degree of the depression but no significant change in the maximal 3H-imipramine binding. After an average of 50 days treatment, Hamilton ratings had returned to normal, but the 3H-imipramine binding values remained unchanged.

Citing Articles

Evolving refractory major depressive disorder diagnostic and treatment paradigms: toward closed-loop therapeutics.

Ward M, Irazoqui P Front Neuroeng. 2010; 3:7.

PMID: 20631824 PMC: 2901135. DOI: 10.3389/fneng.2010.00007.

Specific 3H-imipramine binding in human platelets. Influence of age and sex.

Langer S, Briley M, Raisman R, Henry J, Morselli P Naunyn Schmiedebergs Arch Pharmacol. 1980; 313(3):189-94.

PMID: 7432551 DOI: 10.1007/BF00505732.

3H-imipramine binding and serotonin uptake in platelets from untreated depressed patients and control volunteers.

Raisman R, Briley M, Bouchami F, Sechter D, Zarifian E, Langer S Psychopharmacology (Berl). 1982; 77(4):332-5.

PMID: 6813892 DOI: 10.1007/BF00432765.

3H-Rauwolscine binding in platelets from depressed patients and healthy volunteers.

Pimoule C, Briley M, Gay C, Loo H, Sechter D, Zarifian E Psychopharmacology (Berl). 1983; 79(4):308-12.

PMID: 6407043 DOI: 10.1007/BF00433407.

Short-term lithium administration to healthy volunteers produces long-lasting pronounced changes in platelet serotonin uptake but not imipramine binding.

Poirier M, Galzin A, Pimoule C, Schoemaker H, Le Quan Bui K, Meyer P Psychopharmacology (Berl). 1988; 94(4):521-6.

PMID: 3131797 DOI: 10.1007/BF00212848.

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