Inheritance of Immunoglobulin M Rheumatoid-factor Idiotypes

Overview

Journal J Clin Invest

Specialty General Medicine

Date 1980 Oct 1

PMID 7419724

Citations 18

Authors

J L Pasquali

S Fong

C Tsoukas

J H Vaughan

D A Carson

Affiliations

Soon will be listed here.

Abstract

The idiotypic determinants on IgM rheumatoid factor (RF) from a single family have been analyzed. Rabbit Fab'2 antiidiotypic antibody was prepared against purified IgM-RF from a patient with rheumatoid arthritis. As measured by radioimmunoassay, the antiidiotype reacted with at least 90% of the patient's RF, but not with non-RF immunoglobulins from the same serum, nor with 10 of 11 polyclonal and monoclonal RF from unrelated individuals. Cross-reacting idiotypes were detected on RF in four of the patients' first degree relatives, spanning three generations, without apparent relation of HLA type or clinical rheumatoid arthritis. These results suggest that IgM-RF associated idiotypes were inherited in this family.

Citing Articles

Physiology and pathology of rheumatoid factors.

Carson D, Pasquali J, Tsoukas C, Fong S, Slovin S, Lawrance S Springer Semin Immunopathol. 1981; 4(2):161-79.

PMID: 7323953 DOI: 10.1007/BF01857093.

Autoimmune diseases: immunopathology and etiopathogenesis.

Theofilopoulos A, Dixon F Am J Pathol. 1982; 108(3):319-65.

PMID: 7051837 PMC: 1916035.

Naturally occurring autologous anti-idiotypic antibodies. Participation in immune complex formation in selective IgA deficiency.

Cunningham-Rundles C J Exp Med. 1982; 155(3):711-9.

PMID: 6977608 PMC: 2186614. DOI: 10.1084/jem.155.3.711.

A shared cryoglobulin antigen in familial cryoglobulinemia.

Nightingale S, Pelley R Am J Hum Genet. 1981; 33(5):722-34.

PMID: 6794362 PMC: 1685119.

Idiotypic network: possible explanation of seronegativity in a patient with rheumatoid arthritis.

Pasquali J, Urlacher A, STORCK D Clin Exp Immunol. 1984; 55(2):281-6.

PMID: 6697565 PMC: 1535810.

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