Experimental and Spontaneous Pineal Tumors: Findings Relating to Endocrine and Oncogenic Factors and Mechanisms

Pineocytomas have been induced in a high percentage of hamsters inoculated intracerebrally within 24 hours after birth with particular strains of a human papovavirus. Studies on biochemical and ultrastructural charactertistics and transformation of such experimentally induced pineal tumors have led to important conclusions and implications: (1) Many of the differentiated pineocytoma cells contained organelles and related structures that are characteristic of hamster pineocytes, and others that are reminiscent of possible phylogenetic precursors, including pineal photoreceptor cells. (2) An inverse relationship was noted between degree of cytological differentiation and level of hydroxyindole-O-methyltransferase (HIOMT) activity in the pineocytomas. (3) It is therefore apparent that even when pineal tumor formation leads to great increase in pinealocyte-like cells, their enzymatic capacity for synthesis fo melatonin, and possibly of other humoral products, may be only 4 to 7% of that of normal pinealocytes if they are of a relatively less differentiated type. A number of important and basic questions are accessible and remain to be investigated via experimental pineocytomas, such as: (1) nature and significance of cytological interactions within the pineal; (2) probable occurrences, correlations and transformations of other pineal biosynthetic and hormonal processes; (3) degree and nature of environmental (photic, circadian and circannual factors) and physiologic controls; and (4) kinds of modifications of pineal-related functions.