JC Papovavirus in Progressive Multifocal Leukoencephalopathy

Overview

Journal J Infect Dis

Publisher Oxford University Press

Specialty Infectious Diseases

Date 1976 Jun 1

PMID 778304

Citations 55

Authors

B L PADGETT

D L Walker

G M ZURHEIN

A E Hodach

S M Chou

Affiliations

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Abstract

Brain tissue from seven patients with progressive multifocal leukoencephalopathy was tested for the presence of papovaviruses. JC virus, ahuman papovavirus, was identified in all seven cases. Virus was isolated in tissue culture from extracts from each of four patients and was detected by immunofluorescence in sections from the other three. The new osolates were indistinguishable from the prototypical JC strain serologically and in all biological characteristics examined. Thus JC virus has, to date, been associated with 20 cases of progressive multifocal leukoencephalopathy.

Citing Articles

Revisiting JC virus and progressive multifocal leukoencephalopathy.

Rocchi A, Sariyer I, Berger J J Neurovirol. 2023; 29(5):524-537.

PMID: 37659983 DOI: 10.1007/s13365-023-01164-w.

An Elusive Target: Inhibitors of JC Polyomavirus Infection and Their Development as Therapeutics for the Treatment of Progressive Multifocal Leukoencephalopathy.

Kaiserman J, OHara B, Haley S, Atwood W Int J Mol Sci. 2023; 24(10).

PMID: 37239927 PMC: 10218015. DOI: 10.3390/ijms24108580.

A human-derived 3D brain organoid model to study JC virus infection.

Barreras P, Pamies D, Monaco M, Munoz L, Zhong X, Major E J Neurovirol. 2022; 28(1):17-26.

PMID: 35239145 PMC: 8892818. DOI: 10.1007/s13365-022-01062-7.

IFNα and β Mediated JCPyV Suppression through C/EBPβ-LIP Isoform.

May D, Bellizzi A, Kassa W, Cipriaso J, Caocci M, Wollebo H Viruses. 2021; 13(10).

PMID: 34696366 PMC: 8537971. DOI: 10.3390/v13101937.

CD8 T Cells and STAT1 Signaling Are Essential Codeterminants in Protection from Polyomavirus Encephalopathy.

Mockus T, Netherby-Winslow C, Atkins H, Lauver M, Jin G, Ren H J Virol. 2020; 94(8).

PMID: 31996425 PMC: 7108847. DOI: 10.1128/JVI.02038-19.