A Study of Indoles Which Inhibit Pineal Antigonadotrophic Activity in Male Hamsters

Overview

Journal Endocr Res Commun

Specialty Endocrinology

Date 1975 Jan 1

PMID 1175503

Citations 4

Authors

R J Reiter

M K Vaughan

Affiliations

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Abstract

Blinding adult male golden hamsters led to involution of the testes and accessory sex organs (seminal vesicles and coagulating glands) and to a regression in pituitary prolactin levels within 8 weeks. The subcutaneous implantation of either melatonin or 6-hydroxymelatonin (1 mg/wk in beeswax) prevented the atrophy of the reproductive organs and the decrease in the stores of pituitary prolactin. Two other indoles, N-acetylserotonin and 5-hydroxytryptophol, failed to counteract the reproductive effects of blinding. Both melatonin and 6-hydroxymelatonin significantly elevated plasma LH titers.

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Circadian rhythmicity of the activity of hydroxyindole-O-methyl transferase (HIOMT) in the formation of melatonin and 5-methoxytryptophol in the pineal, retina, and harderian gland of the golden hamster.

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Experimental and spontaneous pineal tumors: findings relating to endocrine and oncogenic factors and mechanisms.

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Alterations in the spontaneous activity of cells in the guinea pig pineal gland and visual system produced by pineal indoles.

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