Alpha 2.0
Login Register
» Articles » PMID: 7370018

Induction of Peroxisomal Beta-oxidation in Rat Liver by High-fat Diets

Overview
Journal Biochem J
Specialty Biochemistry
Date 1980 Jan 15
PMID 7370018
Citations 43
Authors
C E Neat
M S Thomassen
H Osmundsen
Affiliations
Soon will be listed here.
Abstract

Liver peroxisomes were prepared by using a Percoll gradient in a vertical rotor. beta-Oxidation was measured in peroxisomes isolated from livers of rats fed on either high-(15% by wt.) or low- (5% by wt.) fat diets. The feeding of high-fat diets gave a 1.4-2.4-fold increase in total liver peroxisomal beta-oxidation, and a similar increase in specific activity. A 1.5-4.5-fold increase was seen in the specific activity of purified peroxisomal preparations. The reasons for these increases are discussed.

Citing Articles

Interaction between fatty acid oxidation and ethanol metabolism in liver.

Lu Y, George J Am J Physiol Gastrointest Liver Physiol. 2024; 326(5):G483-G494.

PMID: 38573193 PMC: 11901390. DOI: 10.1152/ajpgi.00281.2023.

Fasting induces hepatic lipid accumulation by stimulating peroxisomal dicarboxylic acid oxidation.

Zhang X, Gao T, Deng S, Shang L, Chen X, Chen K J Biol Chem. 2021; 296:100622.

PMID: 33811861 PMC: 8102918. DOI: 10.1016/j.jbc.2021.100622.

Peroxisomal oxidation of erucic acid suppresses mitochondrial fatty acid oxidation by stimulating malonyl-CoA formation in the rat liver.

Chen X, Shang L, Deng S, Li P, Chen K, Gao T J Biol Chem. 2020; 295(30):10168-10179.

PMID: 32493774 PMC: 7383384. DOI: 10.1074/jbc.RA120.013583.

Specific Inhibition of Acyl-CoA Oxidase-1 by an Acetylenic Acid Improves Hepatic Lipid and Reactive Oxygen Species (ROS) Metabolism in Rats Fed a High Fat Diet.

Zeng J, Deng S, Wang Y, Li P, Tang L, Pang Y J Biol Chem. 2017; 292(9):3800-3809.

PMID: 28077576 PMC: 5339762. DOI: 10.1074/jbc.M116.763532.

Erucic acid is differentially taken up and metabolized in rat liver and heart.

Murphy C, Murphy E, Golovko M Lipids. 2008; 43(5):391-400.

PMID: 18350328 DOI: 10.1007/s11745-008-3168-3.

References
1.
Kurup C, Aithal H, Ramasarma T . Increase of hepatic mitochondria on administration of ethyl alpha-p-chlorophenoxyisobutyrate to the rat. Biochem J. 1970; 116(5):773-9. PMC: 1185498. DOI: 10.1042/bj1160773. View
2.
LAMBERTSEN G, MYKLESTAD H, Braekkan O . Studies on monoene fatty acid isomers in hydrogenated fish oils. J Am Oil Chem Soc. 1971; 48(8):389-91. DOI: 10.1007/BF02637357. View
3.
Lazarow P, DE DUVE C . A fatty acyl-CoA oxidizing system in rat liver peroxisomes; enhancement by clofibrate, a hypolipidemic drug. Proc Natl Acad Sci U S A. 1976; 73(6):2043-6. PMC: 430444. DOI: 10.1073/pnas.73.6.2043. View
4.
Blouin A, Bolender R, Weibel E . Distribution of organelles and membranes between hepatocytes and nonhepatocytes in the rat liver parenchyma. A stereological study. J Cell Biol. 1977; 72(2):441-55. PMC: 2110997. DOI: 10.1083/jcb.72.2.441. View
5.
Osumi T, Hashimoto T . Enhancement of fatty acyl-CoA oxidizing activity in rat liver peroxisomes by di-(i-ethylhexyl)phthalate. J Biochem. 1978; 83(5):1361-5. DOI: 10.1093/oxfordjournals.jbchem.a132044. View