Failure of Chlorpromazine to Inhibit Fluid Accumulation Caused by Escherichia Coli Heat-stable Enterotoxin in Suckling Mice

Overview

Journal Infect Immun

Publisher American Society for Microbiology

Specialty Allergy & Immunology

Date 1981 May 1

PMID 7195875

Citations 1

Authors

T Takeda

T Honda

Y Takeda

T MIWATANI

Affiliations

Soon will be listed here.

Abstract

We studied the effect of chlorpromazine on fluid accumulation caused by purified heat-stable enterotoxin (ST) from enterotoxigenic Escherichia coli in suckling mice. We found that chlorpromazine inactivated ST itself in vitro, but did not inhibit the activity of ST in the intestines.

Citing Articles

Characterization of the mechanism of action of Escherichia coli heat-stable enterotoxin.

Dreyfus L, Jaso-Friedmann L, ROBERTSON D Infect Immun. 1984; 44(2):493-501.

PMID: 6143730 PMC: 263547. DOI: 10.1128/iai.44.2.493-501.1984.

References

Wolff J, Jones A . Inhibition of hormone-sensitive adenyl cyclase by phenothiazines. Proc Natl Acad Sci U S A. 1970; 65(2):454-9. PMC: 282924. DOI: 10.1073/pnas.65.2.454. View

SHARP G, Hynie S . Stimulation of intestinal adenyl cyclase by cholera toxin. Nature. 1971; 229(5282):266-9. DOI: 10.1038/229266a0. View

SCHAFER D, Lust W, Sircar B, Goldberg N . Elevated concentration of adenosine 3':5'-cyclic monophosphate in intestinal mucosa after treatment with cholera toxin. Proc Natl Acad Sci U S A. 1970; 67(2):851-6. PMC: 283283. DOI: 10.1073/pnas.67.2.851. View

Evans Jr D, Chen L, Curlin G, Evans D . Stimulation of adenyl cyclase by Escherichia coli enterotoxin. Nat New Biol. 1972; 236(66):137-8. DOI: 10.1038/newbio236137a0. View

Hughes J, Murad F, Chang B, Guerrant R . Role of cyclic GMP in the action of heat-stable enterotoxin of Escherichia coli. Nature. 1978; 271(5647):755-6. DOI: 10.1038/271755a0. View

Takeda T, Takeda Y, MIWATANI T, Ohtomo N . Detection of cholera enterotoxin activity in suckling hamsters. Infect Immun. 1978; 19(2):752-4. PMC: 414145. DOI: 10.1128/iai.19.2.752-754.1978. View

Field M, Graf Jr L, Laird W, Smith P . Heat-stable enterotoxin of Escherichia coli: in vitro effects on guanylate cyclase activity, cyclic GMP concentration, and ion transport in small intestine. Proc Natl Acad Sci U S A. 1978; 75(6):2800-4. PMC: 392652. DOI: 10.1073/pnas.75.6.2800. View

Holmgren J, Lange S, Lonnroth I . Reversal of cyclic AMP-mediated intestinal secretion in mice by chlorpromazine. Gastroenterology. 1978; 75(6):1103-8. View

Rabbani G, Greenough 3rd W, Holmgren J, Lonnroth I . Chlorpromazine reduces fluid-loss in cholera. Lancet. 1979; 1(8113):410-2. DOI: 10.1016/s0140-6736(79)90885-7. View

10.

Lonnroth I, Andren B, Lange S, Martinsson K, Holmgren J . Chlorpromazine reverses diarrhea in piglets caused by enterotoxigenic Escherichia coli. Infect Immun. 1979; 24(3):900-5. PMC: 414392. DOI: 10.1128/iai.24.3.900-905.1979. View

11.

Takeda Y, Takeda T, Yano T, Yamamoto K, MIWATANI T . Purification and partial characterization of heat-stable enterotoxin of enterotoxigenic Escherichia coli. Infect Immun. 1979; 25(3):978-85. PMC: 414544. DOI: 10.1128/iai.25.3.978-985.1979. View

12.

Abbey D, Knoop F . Effect of chlorpromazine on the secretory activity of Escherichia coli heat-stable enterotoxin. Infect Immun. 1979; 26(3):1000-3. PMC: 414718. DOI: 10.1128/iai.26.3.1000-1003.1979. View