Detection of Cholera Enterotoxin Activity in Suckling Hamsters

Overview

Journal Infect Immun

Publisher American Society for Microbiology

Specialty Allergy & Immunology

Date 1978 Feb 1

PMID 631897

Citations 5

Authors

T Takeda

Y Takeda

T MIWATANI

N Ohtomo

Affiliations

Soon will be listed here.

Abstract

For detection of cholera enterotoxin activity, suckling hamster, mouse, and rat models were compared. It was found that not only suckling mice but also suckling rats and hamsters were sensitive to cholera enterotoxin. Among these models, suckling hamsters were the most sensitive and gave positive results with about 1/100 the cholera toxin seen in suckling mice and rats.

Citing Articles

Nanomolar CFTR inhibition by pore-occluding divalent polyethylene glycol-malonic acid hydrazides.

Sonawane N, Zhao D, Zegarra-Moran O, Galietta L, Verkman A Chem Biol. 2008; 15(7):718-28.

PMID: 18635008 PMC: 3322358. DOI: 10.1016/j.chembiol.2008.05.015.

Failure of chlorpromazine to inhibit fluid accumulation caused by Escherichia coli heat-stable enterotoxin in suckling mice.

Takeda T, Honda T, Takeda Y, MIWATANI T Infect Immun. 1981; 32(2):480-3.

PMID: 7195875 PMC: 351470. DOI: 10.1128/iai.32.2.480-483.1981.

Some properties of purified Escherichia coli heat-stable enterotoxin II.

Hitotsubashi S, Fujii Y, Yamanaka H, Okamoto K Infect Immun. 1992; 60(11):4468-74.

PMID: 1398961 PMC: 258190. DOI: 10.1128/iai.60.11.4468-4474.1992.

Purification and partial characterization of heat-stable enterotoxin of enterotoxigenic Escherichia coli.

Takeda Y, Takeda T, Yano T, Yamamoto K, MIWATANI T Infect Immun. 1979; 25(3):978-85.

PMID: 387599 PMC: 414544. DOI: 10.1128/iai.25.3.978-985.1979.

Mechanism of action of Yersinia enterocolitica enterotoxin.

Robins-Browne R, Still C, Miliotis M, Koornhof H Infect Immun. 1979; 25(2):680-4.

PMID: 39894 PMC: 414498. DOI: 10.1128/iai.25.2.680-684.1979.

References

Dutta N, Panse M, Kulkarni D . Role of cholera a toxin in experimental cholera. J Bacteriol. 1959; 78:594-5. PMC: 290591. DOI: 10.1128/jb.78.4.594-595.1959. View

De S . Enterotoxicity of bacteria-free culture-filtrate of Vibrio cholerae. Nature. 1959; 183(4674):1533-4. DOI: 10.1038/1831533a0. View

Lepot A, Banwell J . The Syrian hamster: a reproducible model for studying changes in intestinal fluid secretion in response to enterotoxin challenge. Infect Immun. 1976; 14(5):1167-71. PMC: 415509. DOI: 10.1128/iai.14.5.1167-1171.1976. View

Takeda Y, Okamoto K, MIWATANI T . Toxin from the culture filtrate of Shigella dysenteriae that causes morphological changes in Chinese hamster ovary cells and is distinct from the neurotoxin. Infect Immun. 1977; 18(2):546-8. PMC: 421266. DOI: 10.1128/iai.18.2.546-548.1977. View

Baselski V, Briggs R, Parker C . Intestinal fluid accumulation induced by oral challenge with Vibrio cholerae or cholera toxin in infant mice. Infect Immun. 1977; 15(3):704-12. PMC: 421427. DOI: 10.1128/iai.15.3.704-712.1977. View

Sandefur P, Peterson J . Isolation of skin permeability factors from culture filtrates of Salmonella typhimurium. Infect Immun. 1976; 14(3):671-9. PMC: 420939. DOI: 10.1128/iai.14.3.671-679.1976. View

Honda T, Shimizu M, Takeda Y, MIWATANI T . Isolation of a factor causing morphological changes of chinese hamster ovary cells from the culture filtrate of Vibrio parahaemolyticus. Infect Immun. 1976; 14(4):1028-33. PMC: 415489. DOI: 10.1128/iai.14.4.1028-1033.1976. View

Guerrant R, Brunton L, Schnaitman T, REBHUN L, GILMAN A . Cyclic adenosine monophosphate and alteration of Chinese hamster ovary cell morphology: a rapid, sensitive in vitro assay for the enterotoxins of Vibrio cholerae and Escherichia coli. Infect Immun. 1974; 10(2):320-7. PMC: 414999. DOI: 10.1128/iai.10.2.320-327.1974. View

Gill D . Involvement of nicotinamide adenine dinucleotide in the action of cholera toxin in vitro. Proc Natl Acad Sci U S A. 1975; 72(6):2064-8. PMC: 432694. DOI: 10.1073/pnas.72.6.2064. View

10.

Donta S, Moon H, Whipp S . Detection of heat-labile Escherichia coli enterotoxin with the use of adrenal cells in tissue culture. Science. 1974; 183(4122):334-6. DOI: 10.1126/science.183.4122.334. View

11.

Jacks T, Wu B . Biochemical properties of Escherichia coli low-molecular-weight, heat-stable enterotoxin. Infect Immun. 1974; 9(2):342-7. PMC: 414807. DOI: 10.1128/iai.9.2.342-347.1974. View

12.

Dean A, Ching Y, Williams R, Harden L . Test for Escherichia coli enterotoxin using infant mice: application in a study of diarrhea in children in Honolulu. J Infect Dis. 1972; 125(4):407-11. DOI: 10.1093/infdis/125.4.407. View

13.

Giannella R . Suckling mouse model for detection of heat-stable Escherichia coli enterotoxin: characteristics of the model. Infect Immun. 1976; 14(1):95-9. PMC: 420849. DOI: 10.1128/iai.14.1.95-99.1976. View

14.

Walsh J, YALOW R, Berson S . Detection of Australia antigen and antibody by means of radioimmunoassay techniques. J Infect Dis. 1970; 121(5):550-4. DOI: 10.1093/infdis/121.5.550. View

15.

Sack R, CARPENTER C . Experimental canine cholera. II. Production by cell-free culture filtrates of Vibrio cholerae. J Infect Dis. 1969; 119(2):150-7. DOI: 10.1093/infdis/119.2.150. View

16.

Craig J . A permeability factor (toxin) found in cholera stools and culture filtrates and its neutralization by convalescent cholera sera. Nature. 1965; 207(997):614-6. DOI: 10.1038/207614a0. View