Effect of Chlorpromazine on the Secretory Activity of Escherichia Coli Heat-stable Enterotoxin

Overview

Journal Infect Immun

Publisher American Society for Microbiology

Specialty Allergy & Immunology

Date 1979 Dec 1

PMID 393625

Citations 9

Authors

D M Abbey

F C Knoop

Affiliations

Soon will be listed here.

Abstract

The effect of chlorpromazine on the net intestinal accumulation of fluid induced by Escherichia coli heat-stable (ST) enterotoxin in an infant mouse model was examined. Chlorpromazine, when administered with ST enterotoxin, caused a highly significant decrease in net intestinal fluid accumulation. The inhibition of ST activity was dose dependent with various concentrations of chlorpromazine (P less than 0.001). A significant inhibition of toxic activity was also observed when chlorpromazine was administered before (P less than 0.02) or after (P less than 0.05) ST enterotoxin challenge. No significant differences in fluid accumulation were observed between control mice treated with buffer alone and those treated with only chlorpromazine. These data indicate that chlorpromazine markedly decreases the net intestinal fluid accumulation induced by E. coli ST enterotoxin. Further studies on the potential use of chlorpromazine in both the prophylaxis and the treatment of diarrheal diseases appear warranted.

Citing Articles

Failure of chlorpromazine to inhibit fluid accumulation caused by Escherichia coli heat-stable enterotoxin in suckling mice.

Takeda T, Honda T, Takeda Y, MIWATANI T Infect Immun. 1981; 32(2):480-3.

PMID: 7195875 PMC: 351470. DOI: 10.1128/iai.32.2.480-483.1981.

Berberine inhibits intestinal secretory response of Vibrio cholerae and Escherichia coli enterotoxins.

Sack R, Froehlich J Infect Immun. 1982; 35(2):471-5.

PMID: 7035365 PMC: 351064. DOI: 10.1128/iai.35.2.471-475.1982.

Stimulation of calcium uptake and cyclic GMP synthesis in rat basophilic leukemia cells by Escherichia coli heat-stable enterotoxin.

Knoop F, Thomas D Infect Immun. 1983; 41(3):971-7.

PMID: 6309675 PMC: 264596. DOI: 10.1128/iai.41.3.971-977.1983.

Characterization of the mechanism of action of Escherichia coli heat-stable enterotoxin.

Dreyfus L, Jaso-Friedmann L, ROBERTSON D Infect Immun. 1984; 44(2):493-501.

PMID: 6143730 PMC: 263547. DOI: 10.1128/iai.44.2.493-501.1984.

Lanthanum chloride inhibition of the secretory response to Escherichia coli heat-stable enterotoxin.

Greenberg R, Murad F, Guerrant R Infect Immun. 1982; 35(2):483-8.

PMID: 6120140 PMC: 351066. DOI: 10.1128/iai.35.2.483-488.1982.

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