Molecular Mechanisms of Pyrimidine Dimer Excision in Saccharomyces Cerevisiae: Excision of Dimers in Cell Extracts

Overview

Journal J Bacteriol

Publisher American Society for Microbiology

Specialty Microbiology

Date 1981 Aug 1

PMID 7021538

Citations 9

Authors

R J Reynolds

J D Love

E C Friedberg

Affiliations

Soon will be listed here.

Abstract

Cell-free extracts prepared from rad1-19, rd2-2, rad3-1, rad4-3, rad7-1, rad10-1, rd14-1, rad16-1, and cyc1-1 (rad7) mutants of Saccharomyces cerevisiae all catalyze the preferential excision of thymine-containing pyrimidine dimers from ultraviolet-irradiated DNA specifically incised with M. luteus ultraviolet deoxyribonucleic acid incising activity.

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References

Prakash L, Prakash S . Three additional genes involved in pyrimidine dimer removal in Saccharomyces cerevisiae: RAD7, RAD14 and MMS19. Mol Gen Genet. 1979; 176(3):351-9. DOI: 10.1007/BF00333097. View

BEKKER M, Kaboev O, Akhmedov A, Luchkina L . Ultraviolet-endonuclease activity in cell extracts of Saccharomyces cerevisiae mutants defective in excision of pyrimidine dimers. J Bacteriol. 1980; 142(1):322-4. PMC: 293959. DOI: 10.1128/jb.142.1.322-324.1980. View

BEKKER M, Kaboev O, Kovaltsova S . A new mutant of the yeast Saccharomyces cerevisiae defective in excision of UV-damaged sites in DNA. Mol Gen Genet. 1980; 177(3):541-4. DOI: 10.1007/BF00271495. View

Haseltine W, Gordon L, Lindan C, Grafstrom R, Shaper N, Grossman L . Cleavage of pyrimidine dimers in specific DNA sequences by a pyrimidine dimer DNA-glycosylase of M. luteus. Nature. 1980; 285(5767):634-41. DOI: 10.1038/285634a0. View

Reynolds R, Friedberg E . Molecular mechanisms of pyrimidine dimer excision in Saccharomyces cerevisiae: incision of ultraviolet-irradiated deoxyribonucleic acid in vivo. J Bacteriol. 1981; 146(2):692-704. PMC: 217014. DOI: 10.1128/jb.146.2.692-704.1981. View

HANAWALT P, Cooper P, Ganesan A, Smith C . DNA repair in bacteria and mammalian cells. Annu Rev Biochem. 1979; 48:783-836. DOI: 10.1146/annurev.bi.48.070179.004031. View

Singh A, Sherman F . Deletions of the iso-1-cytochrome c and adjacent genes of yeast: discovery of the OSM1 gene controlling osmotic sensitivity. Genetics. 1978; 89(4):653-65. PMC: 1213858. DOI: 10.1093/genetics/89.4.653. View

Johnston L, Nasmyth K . Saccharomyces cerevisiae cell cycle mutant cdc9 is defective in DNA ligase. Nature. 1978; 274(5674):891-3. DOI: 10.1038/274891a0. View

Reynolds R . Removal of pyrimidine dimers from Saccharomyces cerevisiae nuclear DNA under nongrowth conditions as detected by a sensitive, enzymatic assay. Mutat Res. 1978; 50(1):43-56. DOI: 10.1016/0027-5107(78)90059-3. View

10.

Prakash L . Repair of pyrimidine dimers in radiation-sensitive mutants rad3, rad4, rad6 and rad9 of Saccharomyces cerevisiae. Mutat Res. 1977; 45(1):13-20. DOI: 10.1016/0027-5107(77)90038-0. View

11.

Prakash L . Defective thymine dimer excision in radiation-sensitive mutants rad10 and rad16 of Saccharomyces cerevisiae. Mol Gen Genet. 1977; 152(3):125-8. DOI: 10.1007/BF00268808. View

12.

Lang B, Burger G, Doxiadis I, Thomas D, Bandlow W, Kaudewitz F . A simple method for the large-scale preparation of mitochondria from microorganisms. Anal Biochem. 1977; 77(1):110-21. DOI: 10.1016/0003-2697(77)90295-0. View

13.

Prakash L . Repair of pyrimidine dimers in nuclear and mitochondrial DNA of yeast irradiated with low doses of ultraviolet light. J Mol Biol. 1975; 98(4):781-95. DOI: 10.1016/s0022-2836(75)80010-6. View

14.

Tanaka J, Sekiguchi M . Action of exonuclease V (the recBC enzyme) on ultraviolet-irradiated DNA. Biochim Biophys Acta. 1975; 383(2):178-87. DOI: 10.1016/0005-2787(75)90259-2. View

15.

Livingston D, Richardson C . Deoxyribonucleic acid polymerase III of Escherichia coli. Characterization of associated exonuclease activities. J Biol Chem. 1975; 250(2):470-8. View

16.

Waters R, MOUSTACCHI E . The disappearance of ultraviolet-induced pyrimidine dimers from the nuclear DNA of exponential and stationary phase cells of Saccharomyces cerevisiae following various post-irradiation treatments. Biochim Biophys Acta. 1974; 353(4):407-19. DOI: 10.1016/0005-2787(74)90048-3. View

17.

Chase J, Richardson C . Exonuclease VII of Escherichia coli. Mechanism of action. J Biol Chem. 1974; 249(14):4553-61. View

18.

Friedberg E, Minton K, Pawl G, Verzola P . Excision of thymine dimers in vitro by extracts of bacteriophage-infected Escherichia coli. J Virol. 1974; 13(5):953-9. PMC: 355401. DOI: 10.1128/JVI.13.5.953-959.1974. View

19.

Unrau P, Wheatcroft R, Cox B . The excision of pyrimidine dimers from DNA of ultraviolet irradiated yeast. Mol Gen Genet. 1971; 113(4):359-62. DOI: 10.1007/BF00272336. View

20.

Prakash L, Hinkle D, Prakash S . Decreased UV mutagenesis in cdc8, a DNA replication mutant of Saccharomyces cerevisiae. Mol Gen Genet. 1979; 172(3):249-58. DOI: 10.1007/BF00271724. View