Evidence for an Immunological Relationship Between Streptococcus Mutans and Human Cardiac Tissue

Overview

Journal Infect Immun

Publisher American Society for Microbiology

Specialty Allergy & Immunology

Date 1980 Feb 1

PMID 6991419

Citations 49

Authors

M Hughes

S M Machardy

A J Sheppard

N C WOODS

Affiliations

Soon will be listed here.

Abstract

Two-dimensional immunoelectrophoresis, indirect immunofluorescence, and radioimmunoassay were used to demonstrate that antisera from rabbits immunized with some strains of Streptococcus mutans contain antibodies that cross-react with human cardiac tissue. These rabbits were sensitized to a shocking dose of human heart antigen, and anaphylactic deaths were sometimes produced. Myocarditis was also a result of the immunization procedure. Data obtained with all five techniques were comparable. Cross-reactivity could be associated with three antigens designated ID, IF, and HL. Antigens ID and IF were major immunogens of S. mutans Ingbritt, but HL antibodies were produced only after hyperimmunization. Corss-reactivity was of an immunological nature and not the result of nonspecific factors such as bacterial Fc reactive components or antibody elicited to growth medium constituents. These findings support the hypothesis that immunization with S. mutans can induce autoimmune reactions and indicate that antigens must be selected with caution before formulating any dental caries vaccine.

Citing Articles

Further characterization of immunomodulation by a monoclonal antibody against Streptococcus mutans antigen P1.

Rhodin N, Van Tilburg M, Oli M, McArthur W, Jeannine Brady L Infect Immun. 2003; 72(1):13-21.

PMID: 14688075 PMC: 343944. DOI: 10.1128/IAI.72.1.13-21.2004.

Streptococcus sobrinus antigens that react to salivary antibodies induced by tonsillar application of formalin-killed S. sobrinus in rabbits.

Fukuizumi T, Inoue H, Tsujisawa T, Uchiyama C Infect Immun. 2000; 68(2):725-31.

PMID: 10639439 PMC: 97198. DOI: 10.1128/IAI.68.2.725-731.2000.

Passive immunity against human pathogens using bovine antibodies.

Weiner C, Pan Q, Hurtig M, Boren T, Bostwick E, Hammarstrom L Clin Exp Immunol. 1999; 116(2):193-205.

PMID: 10337007 PMC: 1905285. DOI: 10.1046/j.1365-2249.1999.00880.x.

Surface proteins of gram-positive bacteria and mechanisms of their targeting to the cell wall envelope.

Navarre W, Schneewind O Microbiol Mol Biol Rev. 1999; 63(1):174-229.

PMID: 10066836 PMC: 98962. DOI: 10.1128/MMBR.63.1.174-229.1999.

Tonsillar application of killed Streptococcus mutans induces specific antibodies in rabbit saliva and blood plasma without inducing a cross-reacting antibody to human cardiac muscle.

Fukuizumi T, Inoue H, Tsujisawa T, Uchiyama C Infect Immun. 1997; 65(11):4558-63.

PMID: 9353033 PMC: 175654. DOI: 10.1128/iai.65.11.4558-4563.1997.

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